TGF- β1, bone metabolism, osteoprotegerin, and soluble receptor activator of nuclear factor-kB ligand in girls with anorexia nervosa.

CONCLUSIONS: Changes in bone markers, OPG, and/or OPG/sRANKL ratio observed in girls with AN are associated with changes in serum TGF-β1 concentrations. TGF-β1 suppression in girls with AN might lead to disturbances in the relationship between bone metabolism and the OPG/sRANKL system, which, in turn, might compromise the mechanism compensating for bone remodelling disturbances. (Endokrynol Pol 2016; 67 (5): 493-500).
PMID: 27828689 [PubMed - in process]

Source: Endokrynologia Polska - November 11, 2016 Category: Endocrinology Authors: Ostrowska Z, Ziora K, Oświęcimska J, Świętochowska E, Marek B, Kajdaniuk D, Strzelczyk J, Gołąbek K, Wołkowska-Pokrywa K, Kos-Kudła B Tags: Endokrynol Pol Source Type: research