Nigeria: Studies Show Tomatoes Can Beat Skin Cancer, Male Infertility, Others
[Guardian] Can eating lots tomatoes provide the elusive cure for wrinkles, skin and prostate cancer, hypertension and male infertility?
Publication date: Available online 20 July 2018Source: The LancetAuthor(s): Fatima Marinho, Valéria Maria de Azeredo Passos, Deborah Carvalho Malta, Elizabeth Barboza França, Daisy M X Abreu, Valdelaine E M Araújo, Maria Teresa Bustamante-Teixeira, Paulo A M Camargos, Carolina Cândida da Cunha, Bruce Bartholow Duncan, Mariana Santos Felisbino-Mendes, Maximiliano Ribeiro Guerra, Mark D C Guimaraes, Paulo A Lotufo, Wagner Marcenes, Patricia Pereira Vasconcelos Oliveira, Marcel de Moares Pedroso, Antonio L Ribeiro, Maria Inês Schmidt, Renato Azeredo TeixeiraSummaryBackgroundPolitical, economic...
ConclusionThis endoscopy-based study revealed the most common histology of benign SB tumors were hamartoma and adenoma, and malignant ones were lymphomas, GISTs, adenocarcinomas and metastatic cancers. Most of them were male gender, except for GISTs, and with proximal location, except for lymphomas. Further large-scale investigation efforts are warranted to elucidate the epidemiology of SB tumors.
ConclusionIn this study, half of patients with an ED visit that was primarily for hypertension presented after elevated readings on self-measurement devices. Only 3% of these patients were admitted to the hospital.
Conclusionn-Butanolic fraction of Thymus linearis possesses endothelium independent vasorelaxant effects in coronary artery by direct acting on the smooth muscles. These effects involve the elevation of the cyclic AMP and cyclic GMP possibly through the inhibition of various PDEs. GCMS analysis revel presence of thymole and carvacrol as major constituents. Furthermore, these investigations also support the folklore use of Thymus linearis in hypertension.Graphical abstract
ConclusionsThese findings linked the anti-tumor properties of PE with the immune microenvironment to present a reliable basis for the future practical application of PE in cervical cancer as a novel and pharmacologically safe immunotherapy strategy.Graphical abstract
ConclusionsThe experimental results from the pharmacological research enable the validation of their traditional uses in several of the groups of diseases in the countries of origin and reveal these plants to be a valuable source for therapeutic molecules. However, more toxicity assays and clinical trials would be necessary to establish optimal and safe doses of consumption on the application of these medicinal plants.Graphical abstract
In conclusion, this study makes clear that lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. Overall, our study illustrates that lncRNA THOR/c-myc molecular cascade might be another potent target for retinoblastoma treatment.
Conclusions: AEE protected against 5-Fu-induced intestinal mucositis (IM) in mice through mechanisms that involved in promoting the enterocyte proliferative activity, maintaining the integrity of tight junction proteins, inhibiting oxidative stress and ameliorating the inflammatory disturbances. Accordingly, A. agallocha may be a promising therapeutic candidate used for the prevention of IM during cancer chemotherapy.Graphical abstractThe results of this study gave a scientific support for the protection of AEE on 5-Fu-induced IM in mice through mechanisms that involved in promoting the enterocyte proliferative activity, m...
Publication date: Available online 20 July 2018Source: Cancer EpidemiologyAuthor(s): E.E. Jedy-Agba, E.O. Dareng, S.N. Adebamowo, M. Odutola, E.A. Oga, F. Igbinoba, T. Otu, E. Ezeome, F. Bray, R. Hassan, C.A. Adebamowo
Publication date: Available online 20 July 2018Source: Cancer GeneticsAuthor(s): Daja Šekoranja, Emanuela Bostjančič, Vladka Salapura, Blaž Mavčič, Jože PižemAbstractAneurysmal bone cyst (ABC) is a benign but locally aggressive, mostly pediatric neoplasm, with characteristic USP6 gene rearrangement that distinguishes it from a secondary ABC and other primary bone tumors. With the advent of next-generation sequencing (NGS) technology, several hitherto unknown USP6 fusion partners have been identified in ABC. Accordingly, we present a case of an 18-year-old male with a solid sub-periosteal primary ABC in the di...