The nested graft acts by inducing the process of de ‐senescence of the fibroblasts in chronic venous ulcers

In this study, we introduce full‐thickness micro skin grafts in the ulcer, a surgical technique known as a ‘nested graft’, which gave encouraging results leading to complete wound healing in all patients. The assessment of fibroblast cultures taken from the wound before and after treatment and comparison with fibroblasts from healthy skin showed that the fibroblasts taken from the ulcer after the nested graft treatment acquire morpho‐functional characteristics overlapping those of fibroblasts from healthy skin. This surgical approach is, therefore, able to lead to the healing of chronic ulcers through the de‐senescence of the fibroblasts.

Source: International Wound Journal - March 18, 2015 Category: Surgery Authors: Giulio Gualdi, Silvia Crotti, Paola Monari, Piergiacomo Calzavara ‐Pinton, Massimiliano Vitali, Manuela Baronio, Vassilios Lougaris Tags: ORIGINAL ARTICLE Source Type: research