HRT could cut your dementia risk as it could be triggered by falling oestrogen levels
US researchers found that the initial memory loss marking the beginning of dementia may instead be triggered by the menopause, when levels of the hormone oestrogen plummet.
DEMENTIA is an umbrella term used to describe a set of symptoms that occur when the brain is affected by disease. There ’s currently no cure and no treatment that slows or stops its progression, but there are things you can do to help reduce the risk of getting it.
ConclusionsBy creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives. This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families.
Scientists are peering into the brains of "superagers" in the hope of finding ways to protect others from memory loss
The test involves seeing how fast a person can walk while doing something else at the same time, such as counting backwards or carrying a tray.
Publication date: Available online 21 February 2018 Source:Computational and Structural Biotechnology Journal Author(s): Dimitrios Zafeiris, Sergio Rutella, Graham Roy Ball The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. Artificial Neural Networks (ANN) are some of the most commonly used statistical models and have been successful in biomarker discovery studies in multiple disease types. This review seeks to explore and evaluate an integrated ANN pipeline for biomarker discovery and validation in Alzheimer's disease, the most common ...
Conclusion Understanding paid family-care workers' lived experience in dementia care in South Korea assists with the identification of their educational needs and level of support they require to improve dementia care in the home care environment. A number of suggestions are made to increase paid family-care workers' knowledge, clinical skills, and job satisfaction to reduce their burdens and work-related incidents, such as challenging behaviors from those being cared for.
ConclusionsExperiences of relatives are strongly influenced by the attitudes, expertise and communication that they receive from health professionals working in the hospital. The results clearly show how health professionals have the potential to break through the negative cycle and contribute to a more positive feeling about a patient's hospital stay. Relevance to clinical practiceStructured and individually planned involvement of the relatives during the hospital care seems to be a key aspect for improving the experiences for the relatives and the patients with dementia. Collaboration with the relatives needs to be value...
AbstractIntracellular β-amyloid (Aβ) accumulation is an early event in Alzheimer’s disease (AD) progression. Recently, it has been uncovered that presenilins (PSs), the key components of the amyloid precursor protein (APP) processing and the β-amyloid producing γ-secretase complex, are highly enriched in a special sub-compartment of the endoplasmic reticulum (ER) functionally connected to mitochondria, called mitochondria-associated ER membrane (MAM). A current hypothesis of pathogenesis of Alzheimer’s diseases (AD) suggests that MAM is involved in the initial phase of AD. Since MAM supplie...
Conclusion: Our patient had no further symptoms besides loss of visual acuity, which is rare in patients with VWMD of the same age and genetic mutation.
Conclusion: The variable clinical findings associated with the S170F mutation highlight the relevance of atypical phenotypes in the context of research and under a clinical perspective. CSF sampling and detection of A β species may be essential to indicate AD pathology in unclear cases presenting with cognitive and motor symptoms at a younger age.Neurodegener Dis 2018;18:57-68