Limited role for transforming growth factor-{beta} pathway activation-mediated escape from VEGF inhibition in murine glioma models

Conclusions Our study highlights the biological heterogeneity of murine glioma models and illustrates that cotargeting of the VEGF and TGF-β pathways might lead to improved tumor control only in subsets of glioblastoma.

http://neuro-oncology.oxfordjournals.org/cgi/content/short/18/12/1610?rss=1

Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Mangani, D., Weller, M., Seyed Sadr, E., Willscher, E., Seystahl, K., Reifenberger, G., Tabatabai, G., Binder, H., Schneider, H. Tags: Basic and Translational Investigation Source Type: research