Pharmacokinetics of Imipenem/Cilastatin Burn Intensive Care Unit Patients Undergoing High Dose Continuous Venovenous Hemofiltation

ConclusionEfficient removal of imipenem/cilastatin by high dose CVVH, a high overall clearance, and high volume of distribution in burn intensive care unit patients undergoing this CRRT method warrant aggressive dosing to effectively treat serious infections depending on the infection site and/or pathogen.This article is protected by copyright. All rights reserved.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 8, 2016 Category: Drugs & Pharmacology Authors: Bradley A. Boucher, Joanna Q. Hudson, David M. Hill, Joseph M. Swanson, G. Christopher Wood, S. Casey Laizure, Angela Arnold ‐Ross, Zhe‐Yi Hu, William L. Hickerson Tags: Original Research Article Source Type: research