Darunavir/Ritonavir in HIV-1-Infected Pregnant Women Darunavir/Ritonavir in HIV-1-Infected Pregnant Women

How does pregnancy affect the pharmacokinetics of this antiretroviral regimen?HIV Medicine
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

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Perinatal antiretroviral intensification may prevent intrapartum transmission of HIV in women who start combination antiretroviral therapy (cART) late in pregnancy, new research suggests.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
ConclusionsIn this study, we found that a substantial portion of peripartum women moved within the country around the time of delivery and experienced a significantly higher risk of mortality. Despite the scale-up of universal ART and declining trends in maternal mortality, there is an urgent need to derive a greater understanding of the mechanisms underlying this finding and to develop targeted interventions for mobile HIV-positive peripartum women.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusion: Availability and accessibility of PMTCT programme services are still problematic. The study has the potential to inform development of strategies that may facilitate access to care for PMTCT programme clients. PMID: 32200723 [PubMed - in process]
Source: African Journal of AIDS Research - Category: African Health Tags: Afr J AIDS Res Source Type: research
Authors: Mathad JS, LaCourse SM, Gupta A PMID: 32202066 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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Source: AIDS Care - Category: Infectious Diseases Authors: Source Type: research
Source: Therapeutics and Clinical Risk Management - Category: Drugs & Pharmacology Tags: HIV/AIDS - Research and Palliative Care Source Type: research
CONCLUSIONS: Experiences from the PROMISE study illustrate the challenges of enrolling in longer term studies in the setting of rapidly evolving prevention and treatment standards priorities. The lessons learned will help the community, site investigators, and study coordinators in the design and implementation of future clinical trials. PMID: 32191142 [PubMed - as supplied by publisher]
Source: Clinical Trials - Category: Research Authors: Tags: Clin Trials Source Type: research
Objective: To investigate factors contributing to preterm birth (PTB), including cART use and clinical and social determinants of health, in women living with HIV (WLWH) from British Columbia, Canada. Design: Retrospective observational cohort. Methods: We investigated the effect of cART use and other clinical and demographic factors on spontaneous PTB (sPTB) rates (
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Objectives: Measuring retention is critical for antiretroviral therapy (ART) management and program monitoring; however, many definitions and data sources, usually from single health facilities, are used. We used routine electronic data, linked across facilities, to examine the impact of definitions and data sources on retention estimates among women in Cape Town, South Africa. Design: Retrospective cohort study. Methods: We compiled routine electronic laboratory, pharmacy and clinic visit data for 617 women who started ART during pregnancy (2013–2014) and estimated 24-month retention using different definiti...
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research
Conclusion: Substantial HIV incidence among pregnant and breast-feeding women in SSA, even in the current era of combination HIV prevention and treatment, underscores the need for prevention tailored to high-risk pregnant and breast-feeding women.
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research
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