Cytogam (Cytomegalovirus Immune Globulin Intravenous Human) - updated on RxList

Source: RxList - New and Updated Drug Monographs - Category: Drugs & Pharmacology Source Type: news

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We present data over 4  years on the challenges and efficacy of unmanipulated T cell replete haplo SCTs with post-transplant cyclophosphamide (PTCy) in children diagnosed to have PIDs. We performed a retrospective study in the pediatric blood and marrow transplantation unit where all children less than 18 years of age d iagnosed to have PIDs and who underwent haplo SCT with PTCy from January 2014 to February 2018 were included in the study. Of the 16 transplants included in the study, 5 children were diagnosed to have Wiskott-Aldrich syndrome, 3 with congenital hemophagocytic lymphohistiocytosis, 2 each with Gris...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Cytomegalovirus Infections Interventions:   Biological: V160;   Other: Placebo Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Although a rare entity in Central Europe, the important feature of CMV uveitis is its hypertensive and recurrent nature. In our cases, topical ganciclovir was found to be an effective treatment. Inflammatory activity was well controlled by using an individually assessed prophylactic dose. Larger studies assessing long-term prophylaxis are desirable. PMID: 30763957 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Conclusions: Postintestine transplant infections are ubiquitous in the pediatric population, including high rates of infection from bacterial, viral and fungal sources. Inclusion of the liver and/or colon as a component of the transplant graft did not appear to greatly impact the infectious risk. Adding rituximab to the immunosuppression induction protocol did not impact on infectious risk.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
AbstractHuman cytomegalovirus (HCMV) latency and reactivation is regulated by the chromatin structure at the major immediate early promoter (MIEP) within myeloid cells. Both cellular and viral factors are known to control this promoter during latency, here we will review the known mechanisms for MIEP regulation during latency. We will then focus on the virally encoded G-protein coupled receptor, US28, which suppresses the MIEP in early myeloid lineage cells. The importance of this function is underlined by the fact that US28 is essential for HCMV latency in CD34+ progenitor cells and CD14+ monocytes. We will describe cellu...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
We report our experience with adjuvant antiviral therapy after Kasai portoenterostomy (KP E).
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
This study explored the association of carrying HHV6 and HCMV, and the joint association of carryingHLA-B*13:01 and HHV6 and HCMV with OTHS.MethodsWe recruited 30 OTHS patients and 40 trichloroethylene-exposed healthy workers as cases and controls, respectively.HLA-B*13:01 was genotyped and HHV6 and HCMV DNA were detected in the DNA extracted from whole-blood sample of each participant with PCR techniques. Positive rates ofHLA-B*13:01 gene and HHV6 and HCMV DNA and their association with OTHS were then analyzed.ResultsThe OTHS cases showed significantly higher positive rates ofHLA-B*13:01 gene and HHV6 DNA, but not HCMV DN...
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
CONCLUSIONS: In this study, we found that brain volumes are affected by intrauterine cytomegalovirus infection and that it has a developmental prognostic meaning. Such information, which should be supported by further research, may help clinicians further analyze imaging data to treat and make a better assessment of these fetuses.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: PEDIATRICS Source Type: research
Publication date: February 2019Source: Brain, Behavior, and Immunity, Volume 76, SupplementAuthor(s): J.A. Bosch, N.E. Riddell, K.M. Edwards, S. Hong, P.J. Mills, A.N. Akbar, J.E. Fischer, R.A. van Lier, V.E. Burns, G.R. Wallace, M.T. Drayson, P.A. MossPsychological stress induces a beta-adrenergic dependent mobilization of CD8 + T lymphocytes (CTL) into the peripheral blood. Here we identified infection with Cytomegalovirus (CMV) as a major determinant of this mobilization, and characterized the cellular and transcriptional alterations that underlie enhanced responsivity. During acute stress (TSST), CMV-positive indiv...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: February 2019Source: Brain, Behavior, and Immunity, Volume 76, SupplementAuthor(s): S.J. Wilson, A. Woody, A.C. Padin, J. Lin, W.B. Malarkey, J.K. Kiecolt-GlaserLonely people’s heightened risks for chronic health conditions and early mortality may emerge in part through cellular aging. Lonelier people have more severe responses to acute stress, increasing their risk for herpesvirus reactivation, a possible path to shorter telomeres. Lower parasympathetic activity may modulate this risk. To examine the associations among loneliness, parasympathetic activity, herpesvirus reactivation, and telomere len...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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