Mouse study shows antibody can soothe raging, nerve-driven poison ivy itch

Scientists have developed a strategy to stop the uncontrollable itch caused by urushiol, the oily sap common to poison ivy, poison sumac, poison oak and even mango trees. The team found that by blocking an immune system protein in the skin with an antibody, they could halt the processes that tell the brain the skin is itchy.
Source: ScienceDaily Headlines - Category: Science Source Type: news

Related Links:

We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study we used HPLC and LC/MS analysis, combined with a BATMAN-TCM platform, for detailed HPLC fingerprint analysis and network pharmacology of QP, and investigated the anti-inflammatory and antipruritic activities of QP on ACD induced by squaric acid dibutylester (SADBE) in mice. The BATMAN-TCM analysis provided information of effector molecules of the main ingredients of QP, and possible chronic dermatitis-associated molecules and cell signaling pathways by QP. In ACD mice, QP treatment suppressed the scratching behavior induced by SADBE in a dose-dependent manner and inhibited the production of Th1/2 cytokines in...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
-- If you've been near or touched poison ivy, you may develop an itchy, blistering rash within 12 to 72 hours. Most everyone reacts to an oil in the poison ivy plant called urushiol. The rash typically goes away on its own in a few weeks, but some...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
If you're spending time outdoors in the brush, you're also at higher risk of brushing up against a poisonous plant. Exposure to plants like poison ivy can cause an itchy rash that lasts for weeks.? So how do you treat it? Jason Howland has more in this Mayo Clinic Minute. https://youtu.be/G5mBkVdsoEE Watch: The Mayo Clinic [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et  al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
While flu season is drawing to a close, transmission of germs can still lead to colds and serious respiratory diseases. In few places are individuals more exposed to a multitude of unique germs and germ carriers than during travel. Unlike some forms ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Source Type: blogs
We report 3 cases of scombroid poisoning seen at the Fréjus-Saint-Raphaël hospital in the Var region. OBSERVATIONS: Within around thirty minutes of eating a meal containing tuna, three patients presented varied symptoms: malaise, itchy rash, headache, and for two of them, nausea. The diagnosis of scombroid poisoning was based on the circumstances in which the clinical signs appeared and on the signs themselves. The patients were given antihistamines and one injection of intravenous corticosteroids, and symptoms regressed rapidly within a few hours. DISCUSSION: The symptoms of scombroid poisoning appea...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
Poison ivy or a new perfume making you break out and itch? Your skin normally works as if in harmony to protect you from infection, but sometimes the tune your killer T cells are playing is bad news... -- Read more on ScientificAmerican.com
Source: Scientific American - Category: Science Authors: Tags: Health The Body Source Type: research
Sun poisoning is a relatively uncommon condition similar to a sunburn. In addition to pain, swelling, and itchy skin, it can cause long-term complications.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news
More News: Brain | Itchiness | Mangoes | Neurology | Poisoning | Skin | Study