Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture

Conclusions:
The association between selective autoimmune disease and neurodegenerative disorders unified by the underlying pathology frontotemporal lobar degeneration with TDP-43–positive inclusions (FTLD-TDP) extends to C9 and FTD/MND cohorts, providing further evidence that select autoimmune inflammation may be intrinsically linked to FTLD-TDP pathophysiology.

Source: Neurology Neuroimmunology and Neuroinflammation - November 6, 2016 Category: Neurology Authors: Miller, Z. A., Sturm, V. E., Camsari, G. B., Karydas, A., Yokoyama, J. S., Grinberg, L. T., Boxer, A. L., Rosen, H. J., Rankin, K. P., Gorno-Tempini, M. L., Coppola, G., Geschwind, D. H., Rademakers, R., Seeley, W. W., Graff-Radford, N. R., Miller, B. L. Tags: Autoimmune diseases, Amyotrophic lateral sclerosis, Frontotemporal dementia, Case control studies Article Source Type: research