Ovary regeneration in salamanders could provide solutions to human infertility

(Northeastern University College of Science) Axolotl salamanders are extremely resilient, but very little research has been done on their incredible ability to regenerate internal organs and eggs -- also called oocytes. Examining the axolotl salamander's ability to regenerate ovaries after a traumatic injury and continue to produce nearly 2,000 eggs a year could lead to the development of regenerative medicines aimed at treating infertility in humans.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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Condition:   Infertility, Female Intervention:   Drug: Pre-treatment with rLH (Luveris 75 IU), Sponsors:   Instituto Valenciano de Infertilidad, IVI Alicante;   Merck, S.L., Spain;   Syntax for Science, S.L;   Fundación IVI Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The endoplasmic reticulum-associated protein degradation (ERAD) is responsible for recognizing and retro-translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG-CoA Reductase (HMGCR) Degradation protein—HRD1—was initially identified as an E3 ligase critical for ERAD. However, its physiological functions remain largely undefined. Herein, we discovered that hepatic HRD1 expression is induced in the postprandial condition upon mouse refeeding. Mice with liver-specific HRD1 deletion failed to repress FGF21 production in serum and liver even in the refeeding conditi...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Membrane & Intracellular Transport, Metabolism, Post-translational Modifications, Proteolysis & Proteomics Articles Source Type: research
ConclusionsThe NPS-ASP appears to be a good parameter to assess sperm function and would be a useful tool to detect chromosomal translocations. Four redundant regions have been identified on four chromosomes, suggesting that they may contain genes of interest to study sperm functions.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
This study aims to determine key genes and pathways that could play important roles in the spermatogenic process of patients with cryptorchidism. The identification of these molecules and pathways may help in understanding the etiology of cryptorchidism, and thereby reduce the incidence of cryptorchidism-induced azoospermia. The gene expression profile data of GSE25518 was obtained from the Gene Expression Omnibus (GEO) database. Microarray data were analyzed using BRB-Array Tools to identify differentially expressed genes (DEGs) between high azoospermia risk (HAZR) patients and controls. In addition, other analytical meth...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Authors: Macut D, Milutinović DV, Rašić-Marković A, Nestorov J, Bjekić-Macut J, Stanojlović O Abstract Over the last decade, huge achievements have been made in the fields of neurophysiology, molecular endocrinology, and biochemistry, as well as in the successful translation of clinical research into diseases into clinical practice. As regards female reproduction, most of the advances made in this area were achieved in gonadal axis regulation, regulation of behavior through sex steroids, reproductive genetics, preservation of ovarian reproductive function, steroid profiling, and metabolic and overall re...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Condition:   Infertility Intervention:   Device: KIDScore D3 Sponsor:   Vitrolife Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Infertility Interventions:   Drug: FE 999049;   Other: Placebo Sponsor:   Ferring Pharmaceuticals Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility;   Progesterone;   Frozen Embryo Transfer;   Euploid Embryo Transfer;   Pregnancy Outcome;   Artificial Cycle;   Ongoing Pregnancy Interventions:   Drug: Low Progesterone;   Drug: Normal Progesterone Sponsors:   Institut Universitari Dexeus;   Fundación Santiago Dexeus Font;   Dexeus Mujer Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Infertility Intervention:   Device: KIDScore D3 Sponsor:   Vitrolife Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Infertility Interventions:   Drug: FE 999049;   Other: Placebo Sponsor:   Ferring Pharmaceuticals Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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