Cervical Cancer Radiotherapy by Use of Volumetric Arc Therapy, Polyradiosensitization and Interstitial Brachytherapy.
Condition: Cervical Cancer Interventions: Radiation: Volumetric Arc Radiotherapy; Radiation: Interstitial brachytherapy; Drug: Cisplatin; Drug: Gemcitabine Sponsor: The National Center of Oncology, Azerbaijan Recruiting - verified November 2016
Assess the feasibility, safety and efficacy of Stereotactic ablative radiotherapy (SAbR) as alternative for intracavitary (ICBT) /interstitial brachytherapy (IBT) boost for locally advanced cervical cancer (LACC) after initial chemoradiation
The objective was to determine CD68, CD163, and PD-L1 expression in biopsies from patients with cervical cancer and to compare the effects of HDR vs. PDR brachytherapy on the expression of these proteins.
This phase II study evaluated the utility of MRI and PET for planning radiation and brachytherapy in patients with post-surgical recurrence of cervical cancer.
Conclusion: EF-IMRT is a feasible option for cervical cancer patients with PALN involvement and is associated with acceptable grade III toxicity. Future studies need to focus on minimizing HT toxicity. PMID: 31645885 [PubMed]
In conclusion, the addition of triapine to cisplatin-radiotherapy improved the rate of metabolic complete response in patients with advanced-stage uterine cervix or vaginal cancers without significant toxicity. A phase III trial adequately powered to evaluate progression-free and overall survival is underway (NCT02466971).
We presented the physics preparations and clinical workflow required for implementing MRI-based HDR IBT (MRI-HDR-IBT) of gynecologic cancer patients in a high-volume brachytherapy center. The present document is designed to focus on the clinical steps required from a physicist's standpoint. Those steps include: (a) testing IBT equipment with MRI scanner, (b) preparation of templates and catheters, (c) preparation of MRI line markers, (d) acquisition, importation and registration of MRI images, (e) development of treatment plans and (f) treatment evaluation and documentation. The checklists of imaging acquisition, registrat...
To evaluate local control and survival of high-risk patients with early-stage cervical cancer submitted or not to vaginal cuff brachytherapy in the postoperative setting.
In conclusion, HDR-BT was an effective treatment modality for patients with cervical cancer recurrence in the vaginal stump. PMID: 31579327 [PubMed - in process]
Ultrasound (US) imaging has been proved as an excellent diagnostic tool in gynecology and, due to its wide availability and limited cost, is under intense investigation as base for dose adaptation in cervical ...
CONCLUSIONS: Chemo-brachytherapy is associated with higher acute toxicity with comparable response rates. Small patient numbers and short follow up impedes us from providing conclusive evidence. PMID: 31554360 [PubMed - in process]