Antimicrobial lignans derived from the roots of Streblus asper

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Hui Nie, Xin-Lan Guan, Jian Li, Yan-Jun Zhang, Rui-Jie He, Yan Huang, Bu-Ming Liu, De-Xiong Zhou, Sheng-Ping Deng, Huang-Can Chen, Rui-Yun Yang, Jun Li Four new lignans, (7′R,8′S)-4,4'-Dimethoxy-strebluslignanol (1), 3'-Hydroxy-isostrebluslignaldehyde (2), 3,3'-Methylene-bis(4-hydroxybenzaldehyde) (3), and 4-Methoxy-isomagnaldehyde (4), and six known lignans (5–10), were isolated from the roots of Streblus asper. The structures of these molecules were elucidated through various spectroscopic methods of analysis, including 1D and 2D NMR. The stereochemistry at the chiral centres was determined using the CD spectrum and from coupling constant and optical rotation data. Compounds 1–6 showed good antimicrobial activity against Saccharomyces cerevisiae (ATCC 9763), Bacillus subtilis (ATCC 6633), Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 11775), and Staphylococcus aureus (ATCC 25923), with MIC values ranging from 0.0150 to 0.0940μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research