Genes and age determine susceptibility to Lyme disease

People react very differently to an infection with the Borrelia bacterium that causes Lyme disease. Researchers have investigated this varying response, concluding that age, genetic disposition and previous Lyme infections play an important role. However, despite the large differences observed, the Borrelia bacterium has a clear effect on the immune system ’s energy regulation, opening up opportunities for research into better detection of Borrelia infections.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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We examined gene expression patterns in the blood of individuals with early disseminated LD at the time of diagnosis (Acute LD) and also at approximately 1 month and 6 months following antibiotic treatment. A distinct acute LD profile was observed that was sustained during early convalescence (1 month) but returned to control levels six months after treatment. Using a computer learning algorithm, we identified sets of 20 classifier genes that discriminate LD from other bacterial and viral infections. In addition, these novel LD biomarkers are highly acurate in distinvuishing patients with acute LD from healthy subjects and...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
This article presents the proof-of-concept study for a multivalent OspA vaccine targeting a wide range of pathogenic LB Borrelia species with a single recombinant antigen for prevention of Lyme borreliosis.
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research
Borrelia burgdorferi sensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system binding to purine nucleosides. Nucleosides are essential for bacterial survival in the host organism, and these studies suggest a key role for Bmp...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research
Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Abdul G. Lone, Troy Bankhead
Source: Cell Reports - Category: Cytology Source Type: research
This study aimed to assess whether the serological history of Borrelia infection was associated with the risk of AF. The study included 113 AF patients and 109 patients in sinus rhythm. All patients underwent a clinical evaluation, echocardiography and had t heir blood taken for the assessment of anti-Borrelia IgG antibodies.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusions: This study found a high incidence of Lyme disease in Lithuania. We elucidated the baseline characteristics regarding the infected Lithuanian population which may ease medical clinicians' work on new Lyme diagnoses. PMID: 32151097 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Abstract Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several Europ...
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research
Publication date: Available online 2 March 2020Source: Journal of Structural BiologyAuthor(s): Kalvis Brangulis, Inara Akopjana, Ivars Petrovskis, Andris Kazaks, Kaspars Tars
Source: Journal of Structural Biology - Category: Biology Source Type: research
The black-legged (or deer) tick, Ixodes scapularis, commonly infests dogs in the USA and is the vector of important zoonotic pathogens, including Borrelia burgdorferi, the causative agent of Lyme disease. Rapid o...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Short report Source Type: research
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