Postexertion'Crash,' not Fatigue per se, Marks Syndrome Postexertion'Crash,' not Fatigue per se, Marks Syndrome

New research demonstrates numerous biological abnormalities accompanying and after even minimal exertion among patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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Publication date: Available online 16 July 2019Source: Social Science &MedicineAuthor(s): Sara F. Milrad, Daniel L. Hall, Devika R. Jutagir, Emily G. Lattie, Sara J. Czaja, Dolores M. Perdomo, Gail Ironson, Brian D. Doss, Armando Mendez, Mary Ann Fletcher, Nancy Klimas, Michael H. AntoniAbstractRationaleRelationship dissatisfaction has been linked with worse health outcomes in many patient populations, though the mechanism(s) underlying this effect are unclear. Among patients with chronic fatigue syndrome (CFS) and their partners, there is evidence for a bi-directional association between poorer relationship satisfacti...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Purpose of review The current review aims to determine the recent evidence regarding cause, impact, effective treatment and prognosis of children and young people (CYP) affected by chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) at a time when the National Institute for Clinical Excellence guidelines in the United Kingdom are being reviewed and more research is called for worldwide. Recent findings CFS/ME is a debilitating illness with no clear cause. This review describes the heterogeneous clinical picture and the effects on the young person and family. Comorbidities such as mood disorders and pain are di...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ADOLESCENT MEDICINE: Edited by Sara F. Forman and Sarah Pitts Source Type: research
GRAFTON (CBS) – President Donald Trump singed an executive order Wednesday, revamping the whole approach to treating kidney disease in this country. And a 19-year-old from Grafton is among the 30 million Americans who could benefit. “I just try to keep busy,” said Samantha Cleveland, “so I don’t focus on why I feel so terrible.” Samantha still battles through chronic fatigue to ride her horse, but is well aware that thousands of people die every year waiting for a kidney. “I try not to think about it,” she said, “because right now I’m doing OK.” Samantha Cle...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Donald Trump Grafton News Ken MacLeod kidney donor Source Type: news
Myalgic encephalomyelitis/chronic fatigue syndrome affects at least 2 million people in the United States. Despite its prevalence, there ’s no laboratory test for the disease, and its diagnosis is based on symptoms like exhaustion, unrefreshing sleep, and light sensitivity. For patients with this debilitating condition, getting a diagnosis is often a long and expensive process. Now, a long-awaited biomarker-based test for the myste rious disease could be on the horizon.
Source: JAMA - Category: General Medicine Source Type: research
Conclusions: The concept maps have depicted key concepts relating to the successful delivery of a novel exercise program for people with fatigue and identified specific targets for future program enhancements. Implications for rehabilitation Orthostatic symptoms are common in those with fatigue and might be a target for group-based exercise programs. People with fatigue value a group-based exercise program that targets orthostatic symptoms. The key concepts of a group-based exercise program valued by those with fatigue are the exercises, group atmosphere, physical benefits, self-management support, acceptance, education an...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
This Viewpoint reviews new findings presented at a 2019 NIH conference about neuroendocrine, metabolic, immunologic, and physiologic abnormalities that contribute to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate dehydrogenase (PDH) in ME/CFS. PDH is a crucial enzyme in the mitochondria matrix that links glycolysis to the tricarboxylic acid cycle and oxidative phosphorylation. However, it is little known whether PDH could be a therapeutic target. The purpose of this study was to establish ME/CFS in mi...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
AbstractThe American College of Rheumatology (ACR) 2016 criteria for fibromyalgia (FM) is recommended for use in primary and referral setting. However, neither the ACR 2016 nor its predecessor ACR 2010 criteria have been validated in a referral setting. We hypothesized that the presence of higher comorbidities in the referral care setting may affect the performance of the ACR 2016. All patients referred to a tertiary care hospital with widespread pain for more than 3  months were screened using (1) the ACR 2016 criteria and (2) by a blinded expert physician (using ACR 1990 criteria). Using the ACR 1990 as reference st...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. Th...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Review Source Type: research
Gut Pathogens was founded in 2009 as a journal focusing on enteric infections and aimed at an audience in the Global South and middle income countries. The focus of the first articles remained directed at virulence, epidemiology and genomics of classical pathogens. However, soon after the developments in the field of probiotics turned the journal into a preferred venue for research on this topic. Furthermore, parallel developments in genomics of bacteria resulted in an increase of short articles documenting bacterial genomics, and this led us to create a new short article type called Genome Announcements. Soon after, the s...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Developing World Health Medicine bacterial genomics enteric infections gastroenterology gut gut pathogens gut-brain axis microbiome Source Type: blogs
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