Critical Role of Coaptive Strain in Aortic Valve Leaflet Homeostasis: Use of a Novel Flow Culture Bioreactor to Explore Heart Valve Mechanobiology [Cardiovascular Surgery]

ConclusionsFailure of AV to close initiates an extensive response characterized by expression changes common to progression to calcific aortic valve disease. AV coaptation, whether phasic or chronic, preserved phenotypic gene expression. These results demonstrate, for the first time, that coaptation of valve leaflets is a fundamentally important biomechanical cue driving homeostasis.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Animal Models of Human Disease, Basic Science Research, Etiology, Physiology, Translational Studies Original Research Source Type: research