Red Wine Chemical Enhances Mesothelioma Chemotherapy

A new experimental treatment combining a chemical found in red wine and a popular chemotherapy drug showed a powerful synergistic effect in targeting pleural mesothelioma cells. Researchers at Soon Chun Hyang University Hospital Cheonan in South Korea combined the platinum-based chemotherapy drug cisplatin with resveratrol, a natural antioxidant found in wine and red grapes. The result successfully induced apoptosis, or the process of natural cell death, in malignant mesothelioma cells. Cisplatin has long been one of the most popular drugs to treat mesothelioma and a variety of other cancers. But like many chemotherapy drugs, cisplatin’s efficacy remains limited. Resistance can develop following prolonged cycles or can be present innately in patients. The resveratrol made mesothelioma cells much more vulnerable to cisplatin, an effect Soon Chun Hyang researchers hope will translate into future treatment options. Furthermore, the data showed the increased resistance of the cells is related to the activation of self-defensive autophagy, or the destructive mechanism of the cell that disassembles unnecessary or dysfunctional components. “The molecular basis of the synergistic anti-cancer activities of [cisplatin] and [resveratrol] is not yet understood in detail,” lead investigator Yoon-Jin Lee wrote in the study. “However, emerging studies have revealed that [resveratrol] acts as an excellent candidate for potentiation of platinum treatment in vitro ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: chemotherapy for mesothelioma cisplatin for mesothelioma mesothelioma treatment with red wine red wine for cancer resveratrol and cisplatin for cancer resveratrol in red wine Soon Chun Hyang University Hospital Cheonan Source Type: news

Related Links:

This study reveals important areas of progress in cancer outcomes in Canada since the early 1990s. It also sheds light on cancers for which there has seemingly been no improvement in five-year net survival over a 20-year period. PMID: 30230521 [PubMed - in process]
Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
John Feal believes more people will die from illnesses related to 9/11 than from the terrorist attack at the World Trade Center. He should know. He’s a first responder who witnesses it every day. And he is not alone in his belief. Feal, a longtime advocate for Sept. 11 survivors and those dying from diseases related to the terrorist attacks, will again host the annual naming ceremony at the 9/11 Responders Remembered Park in Smithtown, Long Island. Each year he reads the names of those who have died within the past year. And each year, the list is longer than the last. On the 17th anniversary of the terrorist attack...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   B-cell Acute Lymphoblastic Leukemia;   Lymphoma;   Myeloid Leukemia;   Multiple Myeloma;   Hepatoma;   Gastric Cancer;   Pancreatic Cancer;   Mesothelioma;   Colorectal Cancer;   Esophagus Cancer;   Lung Cancer;   Glioma;   Melanoma;   Synovial Sarcoma;   Ovarian Cancer ;   Renal Carcinoma Intervention:   Biological: CAR-T cell immunotherapy Sponsors:   Shenzhen BinDeBio Ltd.;   The First Affiliated Hospital of Zhengzhou University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study strengthens the suspicion that, next to germline BAP1 alterations, other genetic factors might predispose families to the development of MM,” the authors wrote. Mutations in only one gene called BAP1 have been shown to increase risk of mesothelioma. However, experts suspect other genes may play a role in the disease. This new study supports the idea that other genes can predispose a person — or even an entire family — to mesothelioma. Hints of Genetic Influence on Mesothelioma Risk Asbestos exposure is the No. 1 cause of mesothelioma. However, some families seem to have more cases of mesothe...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
In conclusion, inhibition of ODC1 by DFMO was crucial in facilitating BCT‑100 treatment in lung adenocarcinoma that was partially mediated by depleting arginine and polyamines with consequent apoptosis. PMID: 30066894 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Conclusions: Most cancer outcomes are consistent with background risk in refinery workers. This work has clarified an excess mesothelioma risk, conditional on study quality stratification. Continued surveillance is warranted for melanoma and ALL.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: Original Articles Source Type: research
Standard mesothelioma treatment options include surgery, radiation therapy, chemotherapy and multimodal therapy. These standard therapies do not offer a cure for people with mesothelioma, and that’s why scientists continue searching for better ways to treat the disease. Researchers at the Scripps Research Institute in Jupiter, Florida, have created a precision medicine approach that targets a protein on the surface of cancer cells to kill tumors. Although the drug was not specifically designed for mesothelioma patients, it may offer a more effective way to manage the disease in the future. The treatment is a type of...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Authors: Maxim LD, Utell MJ Abstract This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e.g. overload in chronic inhalation bioassays), but spurred the development of a comprehensive product stewardship program under EPA and later OSHA oversight. Epidemiology studies (both morbidity and mortality) w...
Source: Inhalation Toxicology - Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research
For newly diagnosed mesothelioma patients, standard treatment options include surgery, radiation therapy, chemotherapy and multimodal therapy, which combines these options in various ways. However, more physicians are adding precision medicine to the mix, including targeted therapies such as immunotherapy or drugs aimed at a specific genetic mutation in a tumor. Clinical trials have shown a new drug called AZD5363 attacks a gene that is mutated in some mesothelioma tumors. The drug was not designed for mesothelioma patients, but it may offer another mesothelioma treatment avenue in the future. Limited Options Inspire New T...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
We describe a 57-year-old female patient diagnosed with sporadic MTC. The patient had a history of other neoplasias, such as acute myeloid leukemia, for which she had received chemotherapy, and two other solid tumors, peritoneal mesothelioma and meningioma. Genetic analyses were carried out including whole exome and Sanger sequencing (WES and SS) and loss-of-heterozygosity (LOH) testing for the respective loci. Immunohistochemistry (IHC) was used for the detection of proteins of interest. WES showed two germline variants in the APC and RASAL1 genes confirmed by SS. In MTC tissue only there was a RETvariant identified by SS...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
More News: Asbestosis | Cancer | Cancer & Oncology | Cancer Therapy | Chemistry | Chemotherapy | Clinical Trials | Environmental Health | Grapes | Hospitals | Leukemia | Mesothelioma | Molecular Biology | Study | Toxicology