Fibromyalgia - An Emerging but Controversial Condition - 2014 JAMA Update

Fibromyalgia is not a rheumatological disease but a central pain syndrome. It is a complicated condition that tends to last a long time, although people do get better. The syndrome termed fibromyalgia or fibrositis has attracted the interest of investigators for quite some time. Although some authors believe that fibromyalgia is not a discrete condition, rheumatologists now report that fibromyalgia is one of the most common diagnoses in ambulatory practice. Recent estimates of the prevalence of fibromyalgia in the United States have ranged from 3 to 6 million.This JAMA video introduces a free review article on fibromyalgia from April 2014What is fibromyalgia?Fibromyalgia can be thought of as a centralized pain state. Centralized pain is a lifelong disorder beginning in adolescence or young adulthood manifested by pain experienced in different body regions at different times. How common is fibromyalgia?Fibromyalgia is present in as much as 2% to 8% of the population, is characterized by widespread pain, and is often accompanied by fatigue, memory problems, and sleep disturbances.How to treat fibromyalgia?Numerous treatments are available for managing fibromyalgia that are supported by high-quality evidence:- nonpharmacological therapies (education, exercise, cognitive behavioral therapy)- pharmacological therapies (tricyclics, serotonin norepinephrine reuptake inhibitors, and gabapentinoids)Free content from JAMA:JAMA | Fibromyalgia:  A Clinical Review http://buff.ly/1qH5...
Source: Clinical Cases and Images - Category: Journals (General) Tags: JAMA Rheumatology Source Type: news

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Over the last 12 months New Zealanders have entered into the debate about cannabis and cannabinoids for medical use. In the coming year we’ll hear even more about cannabis as we consider legalising cannabis for recreational use. There is so much rhetoric around the issue, and so much misinformation I thought it high time (see what I did there?!) to write about where I see the research is at for cannabis and cannabinoids for persistent pain. For the purposes of this blog, I’m going to use the following definitions: Cannabis = the plant; cannabis-based medication = registered extracts (either synthetic or from...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Chronic pain Coping strategies Research Science in practice cannabinoids cannabis medicinal cannabis neuropathic pain persistent pain recreational cannabis Source Type: blogs
Publication date: Available online 17 July 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Sizheng Steven Zhao, Stephen J. Duffield, Nicola J. GoodsonAbstractFibromyalgia (FM) is one of the most common conditions that rheumatologists encounter. It is characterised by chronic widespread pain, fatigue, sleep disturbances and impaired cognition. The prevalence of comorbid FM among populations with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are considerably higher than among the general population, with pooled prevalence estimates of 18–24% in RA, 14&n...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
This article presents the case of a 46-year-old woman with fibromyalgia with an undetected fracture of the coccyx. The heterogeneity of the symptoms of patients suffering from fibromyalgia including chronic widespread pain, vegetative and functional disorders, mental and physical exhaustion as well as sleep disorders can cause accidentally undetected comorbidities, especially if these are rare and predominantly present with pain as the main symptom. In the present case the reason for symptoms was detected only after 14 months of ineffective therapies and diagnostic procedures. The coccygeal pain was eliminat...
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research
Conclusion: The results of our study may suggest the presence of FM as a clinical sign of a more severe migraine. However, the long-term prospective studies including these group of patients are needed to understand the prognostic impact and importance of the comorbid FM in migraine. Abbreviations: FM: Fibromyalgia; MIDAS: Migraine Disability Assessment. PMID: 31221031 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Abstract Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
I was looking back over the last 8 years since the first Wheat Belly book was released. It’s been 8 years of astounding, truly breathtaking stories of success over weight issues, health, and physical transformations that skeptics even today claim are impossible. It’s been a virtual avalanche of wonderful stories. Although I’ve seen all of them, often more than once, I could not help but be overcome with satisfaction and pride for the many, many spectacular photos and stories people have shared. So I thought it would be fun to re-post a small sample of some of these stories dating back from the start of th...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories grain-free Inflammation Source Type: blogs
Publication date: June 2019Source: Neurophysiologie Clinique, Volume 49, Issue 3Author(s): Frédéric Viseux, Pascal Charpentier, Antoine LemaireFibromyalgia Syndrome (FMS) is a chronic and multi-faceted disease with an unknown aetiology. Clinical symptoms consisting of widespread pain, generalized muscular hypertonia, fatigue, sleep disturbances, impaired cognition and poor physical fitness compromise the autonomy, function and independence of these patients [1]. Postural control is affected and balance is impaired, leading to a greater risk and frequency of falls [2]. Pain in FMS may be associated with hypere...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
CONCLUSIONS: According to our results, an intense physical rehabilitation program could be considered a promising essential step in the management of FM patients. PMID: 31140398 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
A number of drugs prescribed to treat common conditions, such as hypertension, allergies, depression, inflammation, and diabetes, block your ability to lose weight. Several of these drugs actually cause weight gain, and most doctors fail to inform their patients of such side effects. Among the drugs that block weight loss are: Beta-blockers: metoprolol, atenolol, carvedilol, and propranolol  Antidepressants: amitriptyline (Elavil), nortriptyline (Pamelor), doxepin, paroxetine (Paxil), trazodone, and others Steroids: prednisone and hydrocortisone (but not inhaled or nasal steroids for allergies) Antihistamines: diphen...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates blood sugar drugs failed weight loss fatigue weight loss hypertension insulin prescription drugs undoctored wheat belly Wheat Belly Total Health Source Type: blogs
Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
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