Congenital heart disease and Down syndrome: various aspects of a confirmed association.

CONCLUSION: Our study confirmed that the profile and type of CHD in DS in the Moroccan setting exhibited slight differences in the distribution of these CHDs compared with European neighbours and other Western countries. Further studies are needed to determine which variables have an impact on these differences. PMID: 27805241 [PubMed - in process]
Source: Cardiovascular Journal of Africa - Category: Cardiology Authors: Tags: Cardiovasc J Afr Source Type: research

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Authors: Gökaslan S, DemirbaƟ H, Özer Gökaslan Ç Abstract BACKGROUND/AIM: Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination, and the relapsing?remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used non-invasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-hour Holter ECG monitorin...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Improving the outcomes of pediatric patients with congenital heart disease with end-stage heart failure depends on the collaboration of all stakeholders; this includes providers, patients and families, and industry representatives. Because of the rarity of this condition and the heterogeneity of heart failure etiologies that occur at pediatric centers, learnings must be shared between institutions and all disciplines to move the field forward. To foster collaboration, excel discovery, and bring data to the bedside, a new, collaborative quality improvement science network—ACTION (Advanced Cardiac Therapies Improving O...
Source: ASAIO Journal - Category: Medical Devices Tags: Pediatric Circulatory Support Source Type: research
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Source: Journal of Intellectual and Developmental Disability - Category: Disability Authors: Source Type: research
AbstractPurpose of ReviewIndividuals with metabolically unhealthy normal weight (MUNW) have an adverse cardiometabolic risk factor profile in the absence of excess body weight, and increased risk for diabetes and heart disease. We critically review some physiological traits and lifestyle characteristics of the MUNW phenotype.Recent FindingsThe prevalence of MUNW varies considerably around the world and among ethnicities, partly because of different definitions; on average, this phenotype affects about ~  30% of normal weight persons globally. Most studies have recruited MUNW subjects who, although within the normal ...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Dr. Laura Mulvey, 33, practices emergency medicine at Maimonides Medical Center in Brooklyn, New York. After spending six days receiving treatment in her own hospital, she is now recovering at home from what is presumed to be COVID-19, though her test was inconclusive. What follows is a lightly-edited transcript of her story as told to TIME. Early on, sometime in February, [COVID-19] was something that people were thinking about. And worried about. Certainly, the worries were not what they are now. But hospital-wise, we had a bit of an earlier jump on it, because we recognized that this was a potential threat. We’re ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news
Plans call for enrolling 500 patients worldwide who are under age 50, have been diagnosed with COVID-19 and admitted to an intensive care unit, and have no underlying health problems such as diabetes, heart disease or lung disease.
Source: WebMD Health - Category: Consumer Health News Source Type: news
The hundreds of millions of people in the world breathing polluted air are at high risk for both heart disease and dementia, a new study says.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
The cellular housekeeping mechanisms of autophagy act to recycle proteins and structures within the cell. Upregulation of autophagy appears to be a crucial part of the reason why the response to mild stresses - such as heat, cold, lack of nutrients, and toxins - can actually improve cell and tissue function. Certainly the practice of calorie restriction relies upon functional autophagy in order to extend healthy life span. Researchers here note that autophagy is important in the maintenance of the many stem cell populations throughout the body that are required for ongoing tissue maintenance. The characteristic impairment ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Down syndrome (DS) is one of the most common chromosomal abnormalities. The incidence of DS at birth in developed countries has remained relatively stable over the last 20 years, at approximately 1 per 1000 live births. DS is associated with a number of congenital defects and is also at increased risk of conditions that may develop later in life, and thus requires multidisciplinary care and close surveillance. Congenital heart disease (CHD) is present in 35%–50% of patients and is haemodynamically significant in two-thirds.1 Early diagnosis and treatment in expert centres are essential for improving short-term a...
Source: Heart - Category: Cardiology Authors: Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Interventional cardiology, Epidemiology Editorials Source Type: research
CONCLUSION: The frequency of CHD in our DS cohort is comparable with Europe, Asia ,and other KSA regions. However its pattern appears to be different from some areas in KSA. PMID: 27381537 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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