Estrogen Receptor α Variants Affect Age at Onset of Alzheimer's Disease in a Multiethnic Female Cohort.

Conclusions: ESR1 polymorphisms affect age of onset of AD in women, and risk alleles vary by ethnicity. These effects are possibly due to different linkage disequilibrium patterns or differences in comorbid environmental or cultural risk factors mediating the SNP effect on risk for AD. © 2014 S. Karger AG, Basel. PMID: 24732579 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research