Impact of a prophylactic combination of dexamethasone–ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol–remifentanil anaesthesia: A randomised double-blind placebo-controlled study

CONCLUSION: The combination of dexamethasone and ondansetron was not effective in preventing PONV or severe PONV in obese patients undergoing laparoscopic sleeve gastrectomy after TIVA. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT01876290.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Postoperative nausea and vomiting Source Type: research

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Conclusions: AG confers its antiulcerogenic/antisecretory potentials by repressing the proton pump to increase the gastric juice pH via boosting p-CREB, p-Akt, p-GSK-3β, and GLP-1. Also, it inhibits apoptosis through suppressing nuclear factor-kappa B/tumor necrosis factor-α/H2O2/claudin-1 cue. This trajectory contributes to loosen the tight junction priming AG-mediated GLP-1/β-catenin/cyclin-D1 that results in pronounced increase in gastric mucosa proliferation. Therefore, the crosstalk between multiple pathways orchestrates the action of AG against gastric ulceration.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research
Authors: Sanches E, Timmermans M, Topal B, Celik A, Sundbom M, Ribeiro R, Parmar C, Ugale S, Proczko M, Stepaniak PS, Pujol Rafols J, Mahawar K, Buise MP, Neimark A, Severin R, Pouwels S Abstract Introduction: Obesity is associated with various diseases such as type 2 diabetes, hypertension, obstructive sleep apnea syndrome (OSAS), metabolic syndrome, and cardiovascular diseases. It affects several organ systems, including the pulmonary and cardiac systems. Furthermore, it induces pulmonary and cardiac changes that can result in right and/or left heart failure.Areas covered: In this review, authors provide an overv...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
ConclusionsHOMA-IR can further stratify diabetes risk in AA adults beyond obesity, identifying non-obese high-risk and lower-risk obese individuals. However, diabetes risk should still be carefully monitored in obese populations despite insulin sensitivity.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
Metabolic Syndrome and Related Disorders, Ahead of Print.
Source: Metabolic Syndrome and Related Disorders - Category: Endocrinology Authors: Source Type: research
Publication date: Available online 20 November 2019Source: International Journal of PharmaceuticsAuthor(s): Sim Yee Lim, Mali Dafydd, JieJi Ong, Launa A. Ord-McDermott, Emma Board-Davies, Kirsty Sands, David Williams, Alastair J. Sloan, Charles M. HeardAbstractThere is an unmet clinical need for new products to address the high percentage of the populous who present with periodontal diseases. Drug dose retention at the point of application would facilitate sustained release and more efficacious treatments. The aim of this study was to evaluate mucoadhesive polymeric thin films for simultaneous in situ delivery chlorhexidin...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
The objective of our study was to establish whether increased BMI and lipid profiles affects the prevalence of AO.Methods: Our research was a retrospective case-control study. According to our criteria, 203 patients with AO were included in our study and 94 subjects with no bromhidrosis were matched as the control group. Age, ethnicity, living area, level of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), and body mass index (BMI) were obtained from the clinical data. Logistic regression analysis and multivariate Cox regression analysis...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Plečko M, Bohaček I, Tripković B, Čimić M, Jelić M, Delimar D Abstract Anterior section of the hip joint capsule is innervated by femoral nerve and obturator nerve, and posterior section is innervated by the nerve to quadratus femoris muscle and occasionally by the superior gluteal (posterolateral region) and sciatic nerve (posterosuperior region). One of the regional anesthesia options for hip surgery is the fascia iliaca compartment block (FICB) that affects nerves important for hip innervation and sensory innervation of the thigh - femoral, obturator and lateral femoral cutaneous nerve. FICB can b...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
REGIONAL ANAESTHESIA IN THORACIC AND ABDOMINAL SURGERY. Acta Clin Croat. 2019 Jun;58(Suppl 1):96-100 Authors: Novak-Jankovič V, Markovič-Božič J Abstract Surgical procedure causes tissue damage which activates systemic inflammatory response and leads to changes in endocrine and metabolic system. Anaesthesia and pain can further disrupt immune performance. Regional anaesthesia causes afferent nerve blockade and in this way mediates immune protection. Thoracic epidural analgesia is the cornerstone of pain relief in thoracic and abdominal surgery. Alternatively thoracic paravertebral block can be used...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
This study aimed to examine public opinion about health care VR using social listening, a method that allows for the exploration of unfiltered views of topics discussed on social media and online forums. Methods: In March 2016, NBC News produced a video depicting the use of VR for patient care. The video was repackaged by NowThis, a social media news website, and distributed on Facebook by Upworthy, a news aggregator, yielding 4.3 million views and 2401 comments. We used Microsoft Excel Power Query and ATLAS.ti software (version 7.5, Scientific Software Development) to analyze the comments using content analysis and catego...
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Conclusion Based on extensive medical and scientific studies, health professionals have identified different types of superfoods that are greatly beneficial in promoting a healthy lifestyle. To help health enthusiasts get a better idea of the superfood concept, the comprehensive list above will serve as an important source of information. At the same time, they are given the liberty of incorporating these foods into their daily diets based on their personal preferences. References About the Author Katleen Brown is a health, beauty and fitness writer. She loves to publish her articles on various health related websites...
Source: Life Learning Today - Category: Consumer Health News Authors: Tags: Green Living Healthy Living Recipes food be thy medicine natural healing nutrition superfoods Source Type: blogs
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