Study links first kidney stone event with chronic kidney disease

Ryan MaassROCHESTER, Minn., Nov. 2 (UPI) -- A study of first-time kidney stone formers found subsequent abnormal kidney function connected to higher risk for chronic kidney disease.
Source: Health News - - Category: Consumer Health News Source Type: news

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Abstract Kidney stone disease is a lifestyle-related disease prevalent in developed countries; however, effective medical treatment for the disease is not yet well established. As cellular damage in renal tubular cells (RTCs) is responsible for the disease, here, we focused on the role of macroautophagy/autophagy in RTCs. We found that autophagic activity was significantly decreased in mouse RTCs exposed to calcium oxalate (CaOx) monohydrate crystals and in the kidneys of GFP-conjugated MAP1LC3B (microtubule- associated protein 1 light chain 3 beta) transgenic mice with CaOx nephrocalcinosis induced by glyoxyla...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Abstract BACKGROUND: Matrix-Gla-protein (MGP) is an inhibitor of vascular calcification. Its dephosphorylated and uncarboxylated inactive form, dpucMGP, is a marker of vitamin K status and of cardio-vascular outcomes in chronic kidney disease. We hypothesized that higher serum dpucMGP would be a biomarker of kidney stone disease. METHODS: We measured serum dpucMGP in incident symptomatic kidney stone-formers and non-stone formers at a baseline visit. Symptomatic stone recurrence was assessed in the stones formers over a 5-year period. The association of dpucMGP with incident or recurrent kidney stones was ass...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney has a unique role not only in protecting the host from heat and dehydration but also is an important site of heat-associated disease. Here we review the potential impact of global warming and heat extremes on kidney diseases. High temperatures can result in increased core temperatures, dehydration, and blood hyperosmolality. Heatstroke (both clinical and subclinical whole-body hyperthermia) may have a major role in causing both acute kidney dise...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Publication date: Available online 28 May 2019Source: Molecular Genetics and MetabolismAuthor(s): Hrafnhildur L. Runolfsdottir, Runolfur Palsson, Unnur A. Thorsteinsdottir, Olafur S. Indridason, Inger M.Sch. Agustsdottir, G. Steinunn Oddsdottir, Margret Thorsteinsdottir, Vidar O. EdvardssonAbstractBackgroundAdenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder of adenine metabolism that results in excessive urinary excretion of the poorly soluble 2,8-dihydroxyadenine (DHA), leading to kidney stones and chronic kidney disease. The purpose of this study was to assess urinary DHA excretion...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
This study indicates that urine levels of cytokines involved in chronic inflammation and fibrosis are elevated in urina ry stone formers as early as adolescence. Because stone formers are at risk for chronic kidney disease, macrophage inflammatory protein 1β and interleukin 13 represent investigative targets.
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
Abstract Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
We report a 15-year-old boy referred for nephrocalcinosis. The patient demonstrated hypercalcemia, hypercalciuria, normal serum phosphate level, normal tubular phosphate reabsorption, and increased serum 1,25(OH)2D level with suppressed serum parathyroid hormone. Compound heterozygous mutations in SLC34A3 were found. Hydrochlorothiazide failed to decrease calciuria. Fluconazole, an inhibitor of 1α-hydroxylase, was effective in normalizing calciuria without decreasing glomerular filtration rate. We conclude that children with SLC334A3 mutations can present with a less-typical phenotype, having normal serum phosphate l...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
AbstractTo compare renal functional outcomes in patients with and without chronic kidney disease (CKD) to identify predictors of change in renal function after percutaneous nephrolithotomy (PCNL). We reviewed patients who underwent PCNL by a single surgeon over 3.5  years. Patients’ pre- and post-operative Glomerular Filtration Rate (GFR) was calculated. Baseline GFR   30% decline in renal function post-operatively. Age, gender, African American race, presence of comorbidities and pre-operative CKD were not significant predictors of renal function post-operatively on multivariate analysis. PCNL in ...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
No abstract available
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: CLINICAL NEPHROLOGY: Edited by David S. Goldfarb Source Type: research
ConclusionTimely diagnosis and treatment of APRT deficiency decreases renal complications and preserves kidney function.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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