Association between excessive BMI increase during puberty and risk of cardiovascular mortality in adult men: a population-based cohort study

Publication date: Available online 1 November 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Claes Ohlsson, Maria Bygdell, Arvid Sondén, Annika Rosengren, Jenny M Kindblom Background Being overweight during childhood and adolescence is associated with increased risk of cardiovascular disease in adulthood, but the relative contribution of prepubertal childhood BMI and BMI change during puberty to adult mortality due to cardiovascular disease is unknown. We assessed the contribution of these two distinct developmental BMI parameters for cardiovascular mortality in adult men. Methods As a part of the ongoing population-based BMI Epidemiology Study (BEST) in Gothenburg, Sweden, men born between 1945 and 1961 with information on both their childhood BMI at age 8 years and BMI change during puberty were included in the study and followed up until December, 2013. Participants who died or emigrated before age 20 years were excluded from the analysis. BMI was collected from paediatric growth charts and mandatory military conscription tests. Childhood overweight (BMI of ≥17·9 kg/m2) was defined according to the Centers for Disease Control and Prevention’s cutoff at 8 years of age, and BMI change during puberty was defined as the difference between young adult BMI and childhood BMI (BMI at age 20 years minus BMI at age 8 years). Information on mortality was retrieved from high quality national registers with the participants’ ten-digit personal identi...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research