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Tdap During Pregnancy Not Associated with Microcephaly (FREE)

By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Immunization with the tetanus, diphtheria, and acellular pertussis (Tdap) vaccine during pregnancy is not associated with increased risk for structural birth defects, including microcephaly, according to a …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Abstract OBJECTIVE: To compare pertussis antibody concentrations in maternal venous serum (at the time of delivery) and umbilical cord arterial serum among women vaccinated with the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine from either 27-30 6/7 weeks of gestation or from 31-35 6/7 weeks of gestation. METHODS: We conducted a prospective cohort study of pregnant women divided into two groups based on when Tdap was administered: 27-30 6/7 weeks of gestation and 31-35 6/7 weeks of gestation. Paired maternal and umbilical cord samples were obtained at the time of delivery t...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Despite recommendations from the CDC's Advisory Committee on Immunization Practice and ACOG, tetanus, diphtheria, and acellular pertussis (Tdap) vaccination rates during pregnancy remain very low at about 10%. Vaccinating pregnant women confers passive immunity to infants against pertussis, who experience significantly higher mortality from whooping cough. We sought to highlight the importance of this recommendation by assessing the cost-effectiveness of the Tdap vaccine in pregnant women for preventing pertussis infection in infants.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
Conclusions Although most obstetrician/gynecologists administer some vaccines to pregnant women, the focus remains on influenza and Tdap. Financial barriers and infrequent use of evidence-based strategies for increasing vaccination uptake may be hindering delivery of a broader complement of adult vaccines in obstetrician/gynecologist offices.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Conclusions: The present results indicate a blunting effect after primary vaccination for some serotypes resolving after booster vaccination. Seroprotection rates were comparable both after primary and booster vaccination, except for serotype 3 with a significant lower seroprotection rate in the vaccine group after primary vaccination.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Purpose of review: Maternal vaccination is a well-tolerated and effective way to protect mothers, their developing fetuses, and their young infants from infectious diseases. Although influenza vaccine and diphtheria, tetanus, and acellular pertussis (Tdap) vaccine are recommended for all pregnant women, uptake rates in the United States remain low. This review will focus on the rationale, scientific evidence, and perceptions of vaccination during pregnancy. Recent findings: Recent studies show that administration of influenza and Tdap vaccines during pregnancy is well tolerated and provides protection to the pregnant woma...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: OFFICE PEDIATRICS: Edited by Henry H. Bernstein Source Type: research
Abstract OBJECTIVE: To study characteristics and preventive interventions of adult pregnant and breastfeeding travelers seeking pretravel health care in the United States. METHODS: This cross-sectional study analyzed data (2009-2014) of pregnant and breastfeeding travelers seen at U.S. travel clinics participating in Global TravEpiNet. Nonpregnant, nonbreastfeeding adult female travelers of childbearing age were used for comparison. We evaluated the prescription of malaria chemoprophylaxis and antibiotics for this population as well as the administration of three travel-related vaccines: hepatitis A, typhoid,...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
(Abstracted from Pediatrics 2017;139(5):e20164091) Pertussis is a virulent and life-threatening respiratory infection, particularly in infants, caused by the bacteria Bordetella pertussis. Tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (TDaP) vaccination during pregnancy is recommended to protect newborns against pertussis.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Obstetrics: Preconception and Prenatal Care Source Type: research
Abstract Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during the third trimester of each pregnancy to provide protection to newborns, who are at risk for pertussis-related morbidity and mortality (1). As part of its case-control surveillance study of medications and birth defects, the Birth Defects Study of the Slone Epidemiology Center at Boston University (the Birth Defects Study) has recorded data on vaccinations received during pregnancy since 2006. Among 5,606 mothers of infants without structural birth defects in this population (control group),
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
A CDC study estimated that vaccinating pregnant women with the tetanus, diphtheria and acellular pertussis vaccine during their third trimester was nearly 78 percent effective in preventing pertussis in their infants younger than 2 months.
Source: AAFP News - Category: Primary Care Source Type: news
Timely vaccination can prevent three-quarters of cases in newborns Source: HealthDay Related MedlinePlus Pages: Infections and Pregnancy, Tetanus, Diphtheria, and Pertussis Vaccines, Whooping Cough
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
More News: Diphtheria | Pregnancy | Tetanus | Tetanus Diptheria Pertussis Vaccine Tdap,Dtap,Dpt | Tetanus Vaccine | Vaccines | Whooping Cough (Pertussis) Vaccine