Meet The Doctor Behind The Most Extreme Face Transplant Ever

Last August, Dr. Eduardo Rodriguez performed the most extensive face transplant operation ever.  In the 26-hour operation, which took place at New York University Langone Medical Center, the dentist-turned-plastic-surgeon and his team removed the face and scalp of a young victim of a fatal accident and successfully grafted the tissue onto the head of Patrick Hardison, a firefighter who had been horribly burned in a 2001 fire.  The operation showed in dramatic fashion just how far organ transplantation has come since its start in 1954, when surgeons at Brigham Hospital in Boston took a kidney from one man and gave it to his twin. In the six decades since then, doctors learned how to transplant not just kidneys but also hearts, lungs, livers and other “solid” organs. Now they’re transplanting faces, hands, arms, uteruses, penises and other body parts that ― unlike solid organs ― are made up of multiple tissues, including blood vessels, muscle and bone. “It is an exciting time, and the future of organ transplantation continues to evolve,” Rodriguez told The Huffington Post in an email. Rodriguez wants face transplantation to become the “standard of care for individuals in need.” But this will happen only if some major obstacles are overcome. The high cost of these procedures is one: Who will pay for operations like face transplants, which in the case of the injured firefighter cost an estimated $1 million? Then th...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This reporter group also includes lines driven by ubiquitous promoters like CMV and human ubiquitin C. These are particularly useful for cut-and-paste, transplantation-based experiments to label and fate map regions of host embryos. The second group of reporter expression lines includes transgenics marking subcellular organelles (Supplementary Table S1B). These are highly useful for the study of molecular processes involved in cell function and are especially effective when utilized in the context of Xenopus egg extracts, the only cell-free system that permits full investigation of all DNA transactions related to cell cyc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: We propose that epigenetics mechanisms involving microRNAs may integrate human transplantation tolerance mechanisms, and regulate key members of the cell death/survival signaling. miR-885-5p could favor cell survival in OT by diminishing the levels of CRADD/RAIDD and CASP3. Nonetheless, given the nature of any complex phenomenon in humans, only cumulative data will help to determine whether this microRNA differential profile may be related to the cause or consequence of operational tolerance. Introduction Despite its clinical success, allotransplantation still faces important challenges, such as preventi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are dele...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Anna M. D. Watson1,2*, Eleanor A. M. Gould2, Sally A. Penfold2, Gavin W. Lambert2,3, Putra Riza Pratama2, Aozhi Dai1, Stephen P. Gray2, Geoffrey A. Head2† and Karin A. Jandeleit-Dahm1,2† 1Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia 2Baker Heart and Diabetes Institute, Melbourne, VIC, Australia 3Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, Swinburne University of Technology, Hawthorn, VIC, Australia Patients with diabetic hypertensive nephropathy have accelerated ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions Lymphatic vessels, like blood vessels, are a highly interactive surface for cells of the immune system, and through the use of chemokines and their receptors can coordinate key interactions. These pathways can control the entry and function of particular immune subsets in a number of pathological conditions. Nonetheless LECs have distinct patterns of chemokine secretion and expression of chemokine receptors that distinguish them from the blood vessel system and mediate distinct roles and responses. The abundance and diversity of the chemokine family point to the likelihood that a plethora of novel chemokine fu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Gene-editing technology has accelerated progress on animal organ transplant to the point where scientists will soon begin the first human trialsScientist Wenning Qin holds up a Petri dish, carefully sloshes around the pink liquid inside, and slides it under a microscope. Some identical tiny slashes come into focus. These cells, she explains, are derived from the ear of a pig. And they may contain the future of animal to human organ transplantation.Researchers in South Korea are expected to transplant pig corneasinto humans within a year. A handful of groups across the US are also working toward pig organ clinical trials in...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Gene editing Science Health Organ donation Society Source Type: news
Gene-editing technology has accelerated progress on animal organ transplant to the point where scientists will soon begin the first human trialsScientist Wenning Qin holds up a Petri dish, carefully sloshes around the pink liquid inside, and slides it under a microscope. Some identical tiny slashes come into focus. These cells, she explains, are derived from the ear of a pig. And they may contain the future of animal to human organ transplantation.Researchers in South Korea are expected to transplant pig corneasinto humans within a year. A handful of groups across the US are also working toward pig organ clinical trials in...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Gene editing Science Health Organ donation Society Source Type: news
We examined whether cognitive impairment influences the likelihood for transplant listing and whether patients with cognitive impairment take longer to be listed. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: We conducted a single-center longitudinal cohort study. Patients presenting for their index kidney transplant evaluation were screened for cognitive impairment using the Montreal Cognitive Assessment. A score
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
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