The effectiveness of cinacalcet as an adjunctive therapy for hereditary 1-25 dihydroxyvitamin -D3 resistant rickets.

The effectiveness of cinacalcet as an adjunctive therapy for hereditary 1-25 dihydroxyvitamin -D3 resistant rickets. J Clin Res Pediatr Endocrinol. 2016 Oct 31;: Authors: Akıncı A, Dündar İ, Kıvılcım M Abstract High doses of oral calcium or long-term calcium infusions are recommended to correct the hypocalcemia and secondary hyperparathyroidism in patients with hereditary 1-25 dihydroxyvitamin D3 resistant rickets (HVDRR). Preliminary studies revealed that calcimimetics may be safe and effective therapeutic choise in children with secondary hyperparathyroidism. Our aim was to observe the efficacy of cinacalcet on the normalization of secondary hyperparathroidism and hypophosphatemia in two siblings with VDRR who did not respond to traditional therapy regimes. CASE REPORT: Two siblings with HVDRR , 2.5 years-old and 6 months of age, were admitted to the hospital with severe hypocalcemia. They were treated with high dose of calcitriol and calcium infusions intravenously.Secondary hyperparathroidism was normalized temporarly, but not improve completly. We started cinacalcet (0.25 mg/kg) once a day along with high dose oral calcium and calcitriol, after 3 months biochemical and radiologic findings were return to normal status.We observed that cinacalcet is succesfull to normalize of hyperparathyroidism and hypophosphatemia and to restore bone findings. PMID: 27796266 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research