A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules

Publication date: September 2016 Source:Journal of Saudi Chemical Society, Volume 20, Supplement 1 Author(s): Ruchi Bansal, Karthikeyan Chandrabose, N.S. Hari Narayana Moorthy, Dhirendra Pratap Singh, Digvijay Singh, Piyush Trivedi In this work, a new isocratic reverse phase chromatographic method was developed using HPLC for ziprasidone hydrochloride monohydrate (ZHM). The newly developed method is applicable for assay determination of the ZHM in capsule dosage form. The chromatographic separation of ZHM was achieved on a Zorbax SB C-8 (50×4.6)mm, 3.5μm column within a short runtime of 2min. The method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability. The satisfying recoveries (98–100%) and low coefficient of variation confirmed the suitability of the proposed method for the routine analysis of ZHM in pharmaceuticals.
Source: Journal of Saudi Chemical Society - Category: Chemistry Source Type: research