Commemorating Toxicology at the National Institute of Environmental Health Sciences on the Occasion of Its 50th Anniversary

Author Affiliations open 1Division of the National Toxicology Program (NTP), and 2National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina USA PDF Version (3 MB) Summary About This Article In 1978, the National Toxicology Program (NTP) was established and headquartered at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina. On the occasion of the 50th Anniversary of the NIEHS, this article documents some of the historical and current NTP programs and scientific advances that have been made possible through this long-standing relationship. Citation: Bucher JR, Birnbaum LS. 2016. Commemorating toxicology at the National Institute of Environmental Health Sciences on the occasion of its 50th anniversary. Environ Health Perspect 124:A192–A195; http://dx.doi.org/10.1289/EHP463 Address correspondence to J.R. Bucher, NTP and NIEHS, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4532. E-mail: bucher@niehs.nih.gov The authors wish to acknowledge the helpful discussions with former NTP Associate Directors G. Lucier and C. Portier. The authors declare they have no actual or potential competing financial interests. Final Publication: 1 November 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is acc...
Source: EHP Research - Category: Environmental Health Authors: Tags: Perspectives Brief Communication November 2016 Source Type: research

Related Links:

Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic target. Successful development of such therapeutics requires a detailed understanding of potential on-target toxicities. Here, we identify autosomal dominant mutations of the canonical Notch ligand Jagged1 (or JAG1) as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy Charcot-Marie-T...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Adolescence is a key window of vulnerability for depression, the leading cause of disability worldwide. The prevention of depression among young people is therefore of substantial public health importance. A growing body of large-scale data now support...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Unintentional injuries in and around the home are important causes of preventable death and disability among young children globally. In Nepal, there is a lack of data regarding home injuries and home hazards to guide the development of effecti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
This case highlights the differentiation of dermatofibrosarcoma protuberans from metaplastic breast carcinoma and other spindle cell lesions, as well as the use of imatinib as neoadjuvant treatment.Journal of Medical Case Reports
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Family Medicine/Primary Care Journal Article Source Type: news
Our medical staff just implemented a similar policy. A couple of our surgeons were complaining about it. My group has a mandatory retirement age. EEOC Sues Yale New Haven Hospital for Age and Disability Discrimination
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
States with the highest rates of melanoma cases linked to ultraviolet radiation are spread across the United States on the East and West coasts, in Hawaii and in landlocked states, according to a study published Monday in the International Journal of Cancer.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Some epileptic spasms are classified into focal-onset seizures. However, the cortical network underlying this kind of spasm seizure is not yet clear. Four patients with epileptic spasms who underwent intracranial electrode implantation and focal resection surgery were studied. All the patients had good outcomes, and three of them with intellectual disability showed improved intelligence after surgery. The power spectra characteristics of electrocorticography and the dynamic functional network changes of epileptic spasms were investigated. Electrocorticography power in the resected zone peaked 0.5 seconds before the clinica...
Source: NeuroReport - Category: Neurology Tags: Integrative Systems Source Type: research
Conclusions: Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404 Received: 22 November 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 22 August 2017 Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: (530)...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Life after losing a loved one to vaccines is very painful. With a heavy heart, we share Sebastian Ryan Morley’s story. He was a healthy boy whose life ended after routine vaccinations. Sebastian’s mother and grandmother have worked many years in both the veterinary and human healthcare fields. What they were taught in school led them to believe vaccines were safe, but now they will never vaccinate again. We thank his family for coming forward and sharing very important information the public isn’t usually made aware of. Sebastian’s grandmother, Valerie Murfin, shared: “On December 11, 2002, wh...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Human Top Stories adverse reactions dtap Hepatitis B vaccine Sebastian Ryan Morley truth about vaccines Vaccine Death vaccine injury VAERS Valerie Murfin Source Type: blogs
More News: Academia | Academies | Brain | Brain Cancers | Breast Augmentation | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Chemistry | Child Development | Children | Disability | Education | Emergency Medicine | Environmental Health | Genetics | Grants | Hepatocellular Carcinoma | History of Medicine | International Medicine & Public Health | Lessons | Liver | Liver Cancer | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Nutrition | Occupational Health | Pathology | Perinatology & Neonatology | Plastic Surgery | Politics | Reproduction Medicine | Science | Statistics | Study | Toxicology | Training | Universities & Medical Training | Urology & Nephrology