Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures”

1Rheumatology Department, Royal Cornwall Hospital, Truro, Cornwall, United Kingdom; 2University of Exeter Medical School, Truro, Cornwall, United Kingdom About This Article open Citation: Murphy D, Pay J, Benham R, James B, Hutchinson D. 2016. Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures.” Environ Health Perspect 124:A196; http://dx.doi.org/10.1289/EHP730 Address correspondence to D. Murphy, Rheumatology Department, Royal Cornwall Hospital, Truro, Cornwall, TR1 3LJ United Kingdom. E-mail: daniel.murphy8@nhs.net Support for the authors is provided by Cornwall Arthritis Trust. The authors declare they have no actual or potential competing financial interests. Final Publication: 1 November 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. PDF Version (96 KB) Related EHP Articles Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures Christine G. Parks, Jane A. Hoppin, Anneclaire J. D...
Source: EHP Research - Category: Environmental Health Authors: Tags: Perspectives Correspondence November 2016 Source Type: research

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AbstractNext-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures. Intriguingly, rapidly emerging data indicate that altered genes representing oncogenic drivers can also be found in sporadic non-malignant conditions, some of which have negligible and/or low potential for transformation to cancer. For instance, activatingKRAS mutations are discerned in endometriosis and in brain arteriovenous malformations, inactivatingTP53 tumor suppressor mutations in rheumatoid arthritis synovium, andAKT,MAPK, andAMPK pa...
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
ConclusionsTofacitinib efficacy can be re-established after temporary withdrawal and reinitiation. The safety profile of patients who temporarily discontinued tofacitinib in the sub-study was consistent with previous tofacitinib LTE studies over 9  years.Clinical trial registration numberNCT00413699Key Points•In this sub-study of the long-term extension (LTE) study, ORAL Sequel, the efficacy of tofacitinib was re-established after temporary withdrawal (2  weeks) and reinitation of treatment in patients with RA.•Patients with RA who temporarily discontinued tofacitinib had similar safety events to those ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsHigh treatment satisfaction and alignment were observed among RA patients and their physicians in Latin America. Misaligned patients were more likely to report more severe disease and were less likely to be in remission. Addressing misalignment may lead to improved RA disease control.Key Points• High treatment satisfaction was observed among RA patients and their treating physicians in Latin America.• One-fifth of physician-patient pairs were misaligned in treatment satisfaction.• Patients misaligned with their physicians reported higher disease activity, lower quality of life, and greater disabil...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
In this study, several gene expression data including synovial tissue and macrophages from synovial tissues were integrated with a holistic perspective and the molecular targets and signatures in RA were determined. Differentially expressed genes (DEGs) were identified from each dataset by comparing diseased and healthy samples. Afterward, the RA-specific protein-protein interaction (PPI) and the transcriptional regulatory network were reconstructed by using several biomolecule interaction data. Key biomolecules were determined through a statistical test employing the hypergeometric probability density function by using th...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Authors: Agarwal N, Pangtey GS, Singh R, Sharma SK Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory connective tissue disorder with wide spectrum of presentation from polyarthritis to multisystem involvement. Apart from bones, muscles and other soft tissues, Vitamin D receptors have been found on many immune cells and tissues. The most vital function of Vitamin D is calcium and phosphorus absorption but it can also act as an immune-modulator hormone, which can affects both innate and adaptive immune responses leading to autoimmune diseases. Objectives: To study the relationship of vitami...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionHAQ-UP-A was found to be reliable, valid and reproducible in patients with RA, representing a useful tool for the evaluation of the functional capacity of the upper limbs in these patients.ResumenEl HAQ se considera el estándar de oro para la evaluación de la capacidad funcional en pacientes con artritis reumatoidea (AR), realizando una valoración global de la misma. Con el objetivo de evaluar la incapacidad funcional de la mano en pacientes ancianos con osteoartritis, Baron et al. utilizaron una versión modificada del HAQ al que llamaron 'HAQ-UP'. Este instrumento no ha sido validado ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
We report the first two documented cases in Australia of baricitinib-induced symptomatic elevation of CK.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study. Autoimmunity. 2020 Jan 29;:1-7 Authors: Gomes da Silva IIF, Lima CAD, Monteiro MLA, Barboza DASP, Rushansky E, Mariano MHQA, Sandrin-Garcia P, de Souza PRE, Maia MMD Abstract Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients and its genetic polymorphisms may contribute to the aetiology and pathogenesis of disease in different ethnic groups. P...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
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Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Original Article Source Type: research
Publication date: Available online 25 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ay┼če A. KüçükdeveciAbstractThe goals in the management of established rheumatoid arthritis (RA) are to control pain and disease activity, prevent further joint damage, and enhance functioning and quality of life. Despite the fact that aggressive and the early use of biological and nonbiological disease-modifying antirheumatic drugs have been associated with substantial gains in clinical, radiological, and disability outcomes, a considerable proportion of patients still report significant p...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
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