Institutes in the Lead: Identifying Environmental Factors in Breast Cancer

Since the early 1990s the National Institute of Environmental Health Sciences and the National Cancer Institute have conducted and funded countless studies on potential environmental risk factors for breast cancer. While clear answers are still hard to come by in this highly complex field, increasingly sophisticated research questions and methods have yielded intriguing evidence.© Agence Photographique BSIP/Getty Images A suspected cluster of breast cancer cases on Long Island launched what has become a robust body of evidence on environmental risk factors for breast cancer. The hatching on this map indicate areas where the incidence of breast cancer was statistically higher than the New York state average during the time of the suspected cluster (Long Island lies in the lower right-hand corner).Reprinted by permission from Macmillan Publishers Ltd: Nature Reviews Cancer 5, 986–994, © 2005 Most breast cancers develop in one of two parts of the breast. Lobular cancers form in the structures that produce milk in the lactating woman, while ductal cancers form in the structures that carry milk to the nipple.© Sam and Amy Collins According to the Breast Cancer Fund,4 ductal tumors are much more common than lobular tumors, but the latter are more difficult to diagnose. That means by the time they are identified, lobular tumors tend to be larger and more aggressive. Inflammatory breast cancer is a rare ...
Source: EHP Research - Category: Environmental Health Authors: Tags: News Focus November 2016 Source Type: research

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Authors: Lamy S, Houivet E, Benichou J, Marret S, Thibaut F, Perinatal network of Upper-Normandy Abstract Many pregnant women, in the world, drink caffeine-containing beverages. Maternal caffeine consumption during pregnancy may have adverse effects on foetus but results are conflicting. Our goals were to estimate the prevalence of caffeine use in a cohort of French pregnant women using maternal self-reports and to evaluate the association between caffeine consumption during pregnancy and delivery and newborn characteristics. All pregnant women who gave birth in a large French urban area during a limited period of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Publication date: Available online 22 February 2020Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Jing'an Wang, Dongfang Li, Xin Zhao, Tong Sun, Shengzhen Jin, Hongquan Wang, Tiaoyi Xiao, Yaoguo LiAbstractGrowth hormone (ScGH) and growth hormone receptor (ScGHR) genes from the barbel chub (Squaliobarbus curriculus), in addition to their cDNAs, were cloned. The associations between their mRNA expression levels and growth-related traits were analysed, and the differences in the levels of expression of growth regulation-related genes between the largest and smallest indivi...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
AbstractThree BODIPY ‐peptide conjugates designed to target the epidermal growth factor receptor (EGFR) at the extracellular domain were synthesized and their specificity for binding to EGFR was investigated. Peptide sequences containing seven amino acids, GLARLLT (2) and KLARLLT (3), and 13 amino acids, GYHWYGYTPQNVI (4), were conjugated to carboxyl BODIPY dye (1) by amide bond formation in up to 73% yields. The BODIPY ‐peptide conjugates and their “parent” peptides were determined to bind to EGFR experimentally using SPR analysis, and were further investigated using computational methods (AUTODOCK). Resul...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
When it comes to the management of hypertriglyceridemia-associated acute pancreatitis, is IV insulin or conservative treatment the better option?Journal of the Endocrine Society
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Diabetes & Endocrinology Journal Article Source Type: news
Well aware of the problems in pharmacy, but can't this be cured by electing Bernie Sanders? I am fine with making less money out of the gate if I have my loans wiped out. And as far as not finding a job, I will certainly be less stressed in between jobs if I have universal healthcare and am not worried about going bankrupt from my insulin.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pharmacy Source Type: forums
Contributors : Samuel Jacques ; Almer M van der Sloot ; Caroline Huard ; Jasmin Coulombe-Huntington ; Sarah Tsao ; Sylvain Tollis ; Thierry Bertomeu ; Elizabeth J Culp ; Daniel Pallant ; Michael A Cook ; Eric Bonneil ; Pierre Thibault ; Gerard D Wright ; Michael TyersSeries Type : OtherOrganism : Homo sapiensSystematic genetic interaction profiles can reveal the mechanism-of-action of bioactivecompounds. The imipridone ONC201, which is currently in cancer clinical trials, has beenascribed a variety of different targets. To investigate the genetic dependencies of imipridoneaction, we screened a genome-wide CRISPR knockout l...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Authors: Ceccarelli F, Orefice V, Perrone G, Pirone C, Perricone C, Truglia S, Miranda F, Pacucci VA, Spinelli FR, Galoppi P, Alessandri C, Valesini G, Conti F Abstract OBJECTIVES: We evaluated age at natural menopause and the prevalence of premature ovarian failure (POF) in a monocentric Caucasian cohort of patients with systemic lupus erythematosus (SLE). METHODS: In this cross-sectional study, we enrolled women affected by SLE compared with healthy controls (HC) to investigate data about natural menopause (amenorrhoea for at least 12 months at ≥40 years) and POF (amenorrhoea for at least 12 months at
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
This study demonstrated that citrus PMFs could prevent obesity by activating thermogenesis of BAT and iWAT. PMFs may use as a novel dietary supplemental approach for obesity.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Source: International Journal of Womens Health - Category: OBGYN Tags: International Journal of Women's Health Source Type: research
ConclusionThe incidence of defecation disorders in the geriatric population is high and, most notably, anal incontinence is not spontaneously reported by most patients.ResumoIntroduçãoOs distúrbios da evacuação, seja a incontinência anal ou a constipação intestinal crônica, representam alterações do assoalho pélvico bastante frequente na população em geral e mais comumente naqueles com fatores de risco, ou seja, em idosos, mulheres com passado obstétrico, comorbidades, antecedente de radioterapia pélvica, diab&eacu...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
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