Zika Virus May Affect Male Fertility, According To Study On Mice

CHICAGO (Reuters) - A study of mice infected with Zika showed the virus caused lasting damage to key cells in the male reproductive system, resulting in shrunken testicles, lower levels of sex hormones and reduced fertility, U.S. researchers said on Monday. So far, the findings are only in mice, but the result is worrisome enough to warrant further study because of possible implications for people, said Dr. Michael Diamond of Washington University in St. Louis, whose research was published in the journal Nature. ”It has to be corroborated,” Diamond, a professor of pathology, immunology and molecular microbiology, said in a telephone interview. Much of the global effort to fight Zika has focused on protecting pregnant women from infection because of the grave implications for their unborn children. Zika infections in pregnant women have been shown to cause microcephaly, a severe birth defect in which the head and brain are undersized, as well as other brain abnormalities. Previous studies have shown that Zika can remain in semen for as long as six months. But little is known about whether prolonged exposure to the virus in the testes can cause harm. To study this, Diamond and colleagues injected male mice with Zika. After a week, the researchers recovered infectious virus from the testes and sperm, and they found evidence of viral genes in certain cells of the testes. But overall, the testes appeared normal compared with other lab mice. After three weeks, however, ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Authors: Blot M, Chavanet P, Piroth L Abstract Lower respiratory infections remain the deadliest communicable disease in the world. Influenza infections are particularly involved, whether intrinsically, or more frequently, by promoting bacterial infections and superinfections. The flu is also responsible for the decompensation of many comorbidities and could lead to some myocardial infarction and stroke. The effect of antiviral therapies is limited but preventives measures, such as vaccination, remain a major public health issue. The flu is a major challenge at all levels and all times, from vaccine prevention, to ...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
AbstractIntroduction and hypothesisFemale pelvic organ prolapse (POP) is a common condition, with a lifetime risk for surgery of 10 –20%. Pregnancy and childbirth are the commonest modifiable risk factors for POP, and avulsion of the levator ani muscle is likely to be an etiological factor. Avulsion is more common in instrumental delivery. However, we were unable to identify a meta-analysis on this issue. Our aim was to perfor m a systemic review and quantitative meta-analysis of the prevalence of avulsion relative to delivery mode.MethodsFour electronic databases (MEDLINE, PubMed, Embase, and Google Scholar) were se...
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
AbstractSTUDY QUESTIONAre specific gravity (SG)-adjusted urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA) associated with semen parameters among men attending an academic fertility center?SUMMARY ANSWEROur study did not demonstrate any association between SG-adjusted urinary DCBA concentrations and semen parameters among men attending an academic fertility center.WHAT IS KNOWN ALREADYN,N-Diethyl-m-toluamide (DEET) is the most common active ingredient in consumer insect repellents. The recent rise in public health concerns regarding mosquito-borne diseases such as Zika, have led to an increased use of DEET ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Zika virus is transmitted through mosquitoes and sexual contact and is associated with severe congenital anomalies. The Centers for Disease Control (CDC) recommends that women and men traveling to Zika-affected regions (>70 countries by 2016) delay pregnancy by 8 weeks and 6 months, respectively. We hypothesized that infertile patients may be unwilling to delay conception despite these recommendations. We sought to assess knowledge of Zika virus and if such knowledge influenced reproductive planning among infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
AbstractIn the past 2  years, Zika virus has emerged from obscurity onto the world stage—traversing and transcending clinical specialties, basic science disciplines, and public health efforts. The spread of Zika virus has serious implications for the specialty of reproductive endocrinology and infertility. Our patient s, practices, and labs—worldwide and specifically in the USA—have been impacted by this teratogenic, sexually transmitted, largely asymptomatic virus. While the World Health Organization’s Public Emergency of International Concern designation has lapsed as major epidemics have sub...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Purpose of review: Due to the fact that the Zika virus can be sexually transmitted, there is a potential risk for disease transmission at several stages of assisted reproduction. Such a possibility poses a serious challenge to couples pursing fertility with reproductive technologies. Here, we discuss what is known regarding Zika virus infection with respect to sexual transmission and correlate this knowledge with recent recommendations in the realm of infertility treatment. Recent findings: Zika virus can be transmitted from infected men and women through vaginal, oral or anal intercourse. Zika virus RNA has been detected...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan Antonio Garcia Velasco Source Type: research
Nature Reviews Urology 14, 135 (2017). doi:10.1038/nrurol.2016.265 Author: Andreas Meinhardt Amongst the many causes of male-factor infertility, a diagnosed viral cause is a rather infrequent aetiological factor. However, a recent study has illustrated that Zika virus infections affect not only developing fetuses in pregnant women, but are also a threat to fertility in men. Whether this threat could be managed or mitigated remains uncertain.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Tags: News and Views Source Type: research
The recent Zika virus (ZIKV) epidemic is particularly challenging in the field of reproductive medicine as various biological tissues and byproducts, such as intravenous immunoglobulin G or cells are utilized during reproductive cycles, and an infected mother has an increased risk of having babies with fetal microcephaly and other congenital brain anomalies. In this review, current guidelines for prevention of sexual transmission of ZIKV, ZIKV testing, and tissue and blood product usages are summarized for physicians caring for those planning pregnancy or going through infertility treatment.
Source: American Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: Special Issue Source Type: research
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