Zika Virus May Affect Male Fertility, According To Study On Mice

CHICAGO (Reuters) - A study of mice infected with Zika showed the virus caused lasting damage to key cells in the male reproductive system, resulting in shrunken testicles, lower levels of sex hormones and reduced fertility, U.S. researchers said on Monday. So far, the findings are only in mice, but the result is worrisome enough to warrant further study because of possible implications for people, said Dr. Michael Diamond of Washington University in St. Louis, whose research was published in the journal Nature. ”It has to be corroborated,” Diamond, a professor of pathology, immunology and molecular microbiology, said in a telephone interview. Much of the global effort to fight Zika has focused on protecting pregnant women from infection because of the grave implications for their unborn children. Zika infections in pregnant women have been shown to cause microcephaly, a severe birth defect in which the head and brain are undersized, as well as other brain abnormalities. Previous studies have shown that Zika can remain in semen for as long as six months. But little is known about whether prolonged exposure to the virus in the testes can cause harm. To study this, Diamond and colleagues injected male mice with Zika. After a week, the researchers recovered infectious virus from the testes and sperm, and they found evidence of viral genes in certain cells of the testes. But overall, the testes appeared normal compared with other lab mice. After three weeks, however, ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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This study was to verify the existence and extent of mumps outbreak in Copperbelt province; to describe the epidemiological characteristics of the outbreak; to identify risk factors associated with the illness; to confirm the etiology of the outbreak through appropriate laboratory testing; to inform disease control strategy and advocate for mumps, measles and rubella vaccine in Zambia, which has not yet been implemented.Study designA case report. Clinical records of cases suspected of mumps in the district were reviewed. Cases covered the first 36 weeks of 2015 (January to September, 2015). Charts were generated to capture...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 21 September 2018Source: Social Science &MedicineAuthor(s): B.C. De KokAbstractThis paper explores loss in childbearing in Malawi (miscarriages, perinatal deaths and maternal mortality) as a lens to understand accountability and health system functioning. In low-income countries, maternal and perinatal mortality reflects poor health system functioning, to be improved in part through accountability. Understanding how accountability plays out on the ground requires examination of the existing, ‘organic’ accountability relationships and mechanisms. Thematic and discourse anal...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Abstract BACKGROUND: A growing threat to maternal-fetal health, the most recent and largest outbreak of the Zika virus disease has introduced the devastating fetal effects of microcephaly and other central nervous system deficits. PURPOSE: This brief outlines a history of Zika virus disease, its known effects, best practice recommendations for providers to educate patients, and information for individuals on how to protect themselves. METHODS/SEARCH STRATEGY: A search of the literature using the databases PubMed, UptoDate, and CINAHL was conducted for articles published between 2009 and 2016. Key informa...
Source: Advances in Neonatal Care - Category: Nursing Authors: Tags: Adv Neonatal Care Source Type: research
This report provides updated information and recommendations on testing, screening, and care for pregnant women and infants affected by ZIKV. METHODS: Current published recommendations from the Centers for Disease Control and Prevention, the World Health Organization, and the American Academy of Pediatrics were reviewed and included in this report. RESULTS: Although largely a self-limiting disease usually without symptoms, pregnant women and their fetuses are at greatest risk. Maternal transmission of ZIKV to the fetus can lead to congenital Zika infection with potentially devastating sequelae to the infant. The ...
Source: Advances in Neonatal Care - Category: Nursing Authors: Tags: Adv Neonatal Care Source Type: research
AbstractSTUDY QUESTIONAre specific gravity (SG)-adjusted urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA) associated with semen parameters among men attending an academic fertility center?SUMMARY ANSWEROur study did not demonstrate any association between SG-adjusted urinary DCBA concentrations and semen parameters among men attending an academic fertility center.WHAT IS KNOWN ALREADYN,N-Diethyl-m-toluamide (DEET) is the most common active ingredient in consumer insect repellents. The recent rise in public health concerns regarding mosquito-borne diseases such as Zika, have led to an increased use of DEET ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Zika virus is transmitted through mosquitoes and sexual contact and is associated with severe congenital anomalies. The Centers for Disease Control (CDC) recommends that women and men traveling to Zika-affected regions (>70 countries by 2016) delay pregnancy by 8 weeks and 6 months, respectively. We hypothesized that infertile patients may be unwilling to delay conception despite these recommendations. We sought to assess knowledge of Zika virus and if such knowledge influenced reproductive planning among infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
AbstractIn the past 2  years, Zika virus has emerged from obscurity onto the world stage—traversing and transcending clinical specialties, basic science disciplines, and public health efforts. The spread of Zika virus has serious implications for the specialty of reproductive endocrinology and infertility. Our patient s, practices, and labs—worldwide and specifically in the USA—have been impacted by this teratogenic, sexually transmitted, largely asymptomatic virus. While the World Health Organization’s Public Emergency of International Concern designation has lapsed as major epidemics have sub...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Purpose of review: Due to the fact that the Zika virus can be sexually transmitted, there is a potential risk for disease transmission at several stages of assisted reproduction. Such a possibility poses a serious challenge to couples pursing fertility with reproductive technologies. Here, we discuss what is known regarding Zika virus infection with respect to sexual transmission and correlate this knowledge with recent recommendations in the realm of infertility treatment. Recent findings: Zika virus can be transmitted from infected men and women through vaginal, oral or anal intercourse. Zika virus RNA has been detected...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan Antonio Garcia Velasco Source Type: research
Nature Reviews Urology 14, 135 (2017). doi:10.1038/nrurol.2016.265 Author: Andreas Meinhardt Amongst the many causes of male-factor infertility, a diagnosed viral cause is a rather infrequent aetiological factor. However, a recent study has illustrated that Zika virus infections affect not only developing fetuses in pregnant women, but are also a threat to fertility in men. Whether this threat could be managed or mitigated remains uncertain.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Tags: News and Views Source Type: research
The recent Zika virus (ZIKV) epidemic is particularly challenging in the field of reproductive medicine as various biological tissues and byproducts, such as intravenous immunoglobulin G or cells are utilized during reproductive cycles, and an infected mother has an increased risk of having babies with fetal microcephaly and other congenital brain anomalies. In this review, current guidelines for prevention of sexual transmission of ZIKV, ZIKV testing, and tissue and blood product usages are summarized for physicians caring for those planning pregnancy or going through infertility treatment.
Source: American Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: Special Issue Source Type: research
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