New guaiane and acorane sesquiterpenes in high quality agarwood ⿿Qi-Nan⿿ from Aquilaria sinensis

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Delan Yang, Jun Wang, Wei Li, Wenhua Dong, Wenli Mei, Haofu Dai Two new guaiane sesquiterpenes (1⿿2), one new acorane sesquiterpene (3), along with two known sesquiterpenes (4⿿5) were isolated from high quality agarwood ⿿Qi-Nan⿿ originating from Aquilaria sinensis. Their structures were established based on spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR. Compound 1 was a guaiane sesquiterpene lactone, and compound 2 was a guaiane sesquiterpene with a 5/6/7 ring carbon skeleton. Compounds 3 and 4 were acorane-type sesquiterpenes. The two acorane sesquiterpenes (3⿿4) possess lasting fragrant smell at room temperature. These isolated guaiane and acorane sesquiterpenes showed acetylcholinesterase inhibitory activities in different degrees ranged from 19% to 44% at the concentration of 50μg/mL. Graphical abstract

Source: Phytochemistry Letters - October 28, 2016 Category: Chemistry Source Type: research