Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Liu-hong Zhang, Yi Long, Xiao-ling Lei, Jia-yi Xu, Zhi-jian Huang, Zhi-gang She, Yong-cheng Lin, Jing Li, Lan Liu Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures of 1–8 were elucidated by 1D and 2D NMR analysis. The absolute configurations of 1–4 were determined by electronic circular dichroism (ECD). The isolated compounds were evaluated for cytotoxic activity against two tumor cell lines and antibacterial activities against twelve aquatic pathogenic bacteria. Graphical abstract

Source: Phytochemistry Letters - October 28, 2016 Category: Chemistry Source Type: research