Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Wen-Juan Yuan, Guo-Ping Yang, Jia-Hui Zhang, Yu Zhang, Duo-Zhi Chen, Shun-Lin Li, Ying-Tong Di, Xiao-Jiang Hao From the roots of Euphorbia ebracteolata Hayata, three new diterpenes, Ebracteolatas A–C, based on the rosane (1–2) and lathyrane (3) skeleton, were isolated together with four known ones (4–7). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 6, and 7 exhibited moderate cytotoxic effects against five cancer cell lines. Graphical abstract

Source: Phytochemistry Letters - October 28, 2016 Category: Chemistry Source Type: research