Association Between Short-Term Exposure to PM2.5 and PM10 and Mortality in Susceptible Subgroups: A Multisite Case-Crossover Analysis of Individual Effect Modifiers.

Association Between Short-Term Exposure to PM2.5 and PM10 and Mortality in Susceptible Subgroups: A Multisite Case-Crossover Analysis of Individual Effect Modifiers.
Am J Epidemiol. 2016 Oct 25;
Authors: Alessandrini ER, Stafoggia M, Faustini A, Berti G, Canova C, De Togni A, Di Biagio K, Gherardi B, Giannini S, Lauriola P, Pandolfi P, Randi G, Ranzi A, Simonato L, Zauli Sajani S, Cadum E, Forastiere F, , on behalf of the EpiAir2 Study Group
Abstract
We performed a multisite study to evaluate demographic and clinical conditions as potential modifiers of the particulate matter (PM)-mortality association. We selected 228,619 natural deaths of elderly persons (ages ≥65 years) that occurred in 12 Italian cities during the period 2006-2010. Individual data on causes of death, age, sex, location of death, and preexisting chronic and acute conditions from the previous 5 years' hospitalizations were collected. City-specific conditional logistic regression models were applied within the case-crossover "time-stratified" framework, followed by random-effects meta-analysis. Particulate matter less than or equal to 2.5 µm in aerodynamic diameter (PM2.5) and particulate matter less than or equal to 10 µm in aerodynamic diameter (PM10) were positively associated with natural mortality (1.05% and 0.74% increases in mortality risk for increments of 10 µg/m(3) and 14.4 µg/m(3), respectively), with greater effects being seen among older people, t...

Source: Am J Epidemiol - October 24, 2016 Category: Epidemiology Authors: Alessandrini ER, Stafoggia M, Faustini A, Berti G, Canova C, De Togni A, Di Biagio K, Gherardi B, Giannini S, Lauriola P, Pandolfi P, Randi G, Ranzi A, Simonato L, Zauli Sajani S, Cadum E, Forastiere F, , on behalf of the EpiAir2 Study Group Tags: Am J Epidemiol Source Type: research