Vancomycin Trough and Acute Kidney Injury: A Large Retrospective, Cohort Study

Background: The association between vancomycin trough (VT) and acute kidney injury (AKI) at the recommended doses remains controversial.Methods: The authors conducted a retrospective, observational cohort study of 500 adult patients who received vancomycin for ≥72 h. Data collected included 2 main predictors: average VT (including only VTs before the occurrence of AKI), first VT and other possible risk factors for AKI. The baseline characteristics/variables between patients with AKI and patients with no AKI were compared. Logistic regression models were used to develop multivariate models. The authors divided the patients into 4 subgroups: (1) VT15 μg/ml as this is associated with increased incidence of AKI.Am J Nephrol 2016;44:456-461

Source: American Journal of Nephrology - October 27, 2016 Category: Neurology Source Type: research