Statin-Associated Muscle Symptoms. Position paper from the Luso-Latin American Consortium.

Statin-Associated Muscle Symptoms. Position paper from the Luso-Latin American Consortium.
Curr Med Res Opin. 2016 Oct 25;:1-38
Authors: Sposito AC, Faria Neto JR, Carvalho LS, Lorenzatti A, Cafferata A, Elikir G, Esteban E, Morales Villegas EC, Bodanese LC, Alonso RK, Morales AJ, Rocha VZ, Faludi AA, Xavier HT, Coelho OR, Assad MH, Izar MC, Santos RD, Fonseca FA, Mello E Silva A, Silva PM, Bertolami MC
Abstract
In the last 2 decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been appointed as one of the most important elements for the reduction of the cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS allowed a deeper understanding of the natural history and the accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, this Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this do...

Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research