Diagnostic Value of Sepsis Biomarkers in Hematopoietic Stem Cell Transplant Recipients in a Condition of High Prevalence of Gram-negative Pathogens

Conclusion] Presepsin may be recommended in adult patients with suspected gram-negative BSI after HSCT as a possible additional supplementary test with a cut-off value of 218 pg/mL. PCT is inferior to presepsin in terms of sensitivity and specificity, but still shows a good quality of diagnostic value with an optimal cut-off value of 1.5 ng/mL. CRP showed an average diagnostic value with low sensitivity (40%) and should not be routinely recommended as a biomarker in adult patients with suspected BSI after HSCT in a condition of high prevalence of gram-negative pathogens.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research