Nonadherent Spheres With Multiple Myeloma Surface Markers Contain Cells that Contribute to Sphere Formation and Are Capable of Internalizing Extracellular Double-Stranded DNA.

CONCLUSION: Nonadherent 3-D cell colonies (spheres) encompass B cells with CD73/CD20(+)/CD45(+)/CD19(dim) phenotype, as well as double-stranded DNA-internalizing cells. The latter cell type appears to function as a sphere-forming center. Different cells in the spheres communicate with each other by secreting specific sets of cytokines. For successful engraftment and tumor growth in mice, intact spheres containing ∼ 10(6) cells must be used.
PMID: 27431933 [PubMed - in process]

Source: Clinical Lymphoma and Myeloma - September 30, 2016 Category: Cancer & Oncology Authors: Dolgova EV, Shevela EY, Tyrinova TV, Minkevich AM, Proskurina AS, Potter EA, Orishchenko KE, Zavjalov EL, Bayborodin SI, Nikolin VP, Popova NA, Pronkina NV, Ostanin AA, Chernykh ER, Bogachev SS Tags: Clin Lymphoma Myeloma Leuk Source Type: research