Prothrombin and factor X are elevated in multiple sclerosis patients

This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing‐remitting and secondary‐progressive MS had significantly higher prothrombin and factor X levels than healthy donors (HD), while levels were unchanged in primary‐progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies. This article is protected by copyright. All rights reserved.

Source: Annals of Neurology - September 30, 2016 Category: Neurology Authors: Kerstin G öbel, Peter Kraft, Susann Pankratz, Catharina C. Gross, Catharina Korsukewitz, Robert Kwiecien, Rolf Mesters, Beate Kehrel, Heinz Wiendl, Christoph Kleinschnitz, Sven G. Meuth Tags: Brief Communication Source Type: research