Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.

CONCLUSION: We conclude that freshly isolated and neurosphere-grown MGE cells reduced seizures by different mechanisms (inhibitory interneurons vs. astrocytes). Fresh MGE cells appear more appropriate for cell therapies targeting inhibitory interneurons for conferring anticonvulsant outcomes.
PMID: 27770487 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - October 20, 2016 Category: Neuroscience Authors: Romariz SA, Paiva DS, Galindo LT, Barnabé GF, Guedes VA, Borlongan CV, Longo BM Tags: CNS Neurosci Ther Source Type: research