Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

Conclusion
Our studies demonstrate that the expression of many lncRNAs is dynamically regulated in ICM. lncRNAs regulate the expression and function of ECM and cardiac fibrosis during the development of ICM. Our results further indicate that lncRNAs may represent novel regulators of heart function and cardiac disorders, including ICM.

Source: Cardiovascular Research - October 20, 2016 Category: Cardiology Authors: Huang, Z.-P., Ding, Y., Chen, J., Wu, G., Kataoka, M., Hu, Y., Yang, J.-H., Liu, J., Drakos, S. G., Selzman, C. H., Kyselovic, J., Qu, L.-H., dos Remedios, C. G., Pu, W. T., Wang, D.-Z. Tags: Cardiac biology and remodelling Source Type: research