Inherited Pain Syndromes and Ion Channels

Individuals rely on the perception of pain to avoid injury, signal disease and warn about tissue inflammation and damage. However, the inheritance of inappropriate, extreme or inadequate pain production is a source of significant human suffering.Substantial progress has been made in our understanding of the genetics and pathophysiology of pain through the study of individuals and families with several specific inherited pain syndromes. These studies have led to the discovery of a number of gene mutations associated with specific ion channel disturbances that produce familial inherited pain sensitivity and insensitivity syndromes.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research
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