TCF7L2 and CCND1 polymorphisms and its association with colorectal cancer in Mexican patients.

TCF7L2 and CCND1 polymorphisms and its association with colorectal cancer in Mexican patients. Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):13-20 Authors: Rosales-Reynoso MA, Arredondo-Valdez AR, Juárez-Vázquez CI, Wence-Chavez LI, Barros-Núñez P, Gallegos-Arreola MP, Flores-Martínez SE, Morán-Moguel MC, Sánchez-Corona J Abstract Accumulative evidence suggests that alterations due to mutations or genetic polymorphisms in the TCF7L2 and CCND1 genes, which are components of the Wnt signaling pathway, contributes to carcinogenesis. The present study was designated to clarify whether common single nucleotide polymorphisms (SNPs) of the transcription factor 7- like 2 (TCF7L2) and cyclin D1 (CCND1) genes are associated with colorectal cancer risk in Mexican patients. A case-control study including 197 colorectal cancer patients and 100 healthy subjects was conducted in a Mexican population. Identification of polymorphisms was made by the polymerase chain reaction-restriction fragment length polymorphism methodology. The association was calculated by the odds ratio (OR) test. The results demonstrate that patients with the T/T genotype for the rs12255372 polymorphism of the TCF7L2 gene present an increased colorectal cancer risk (OR=2.64, P=0.0236). Also, the risk analysis for Tumor-Nodule-Metastasis (TNM) stage and tumor location showed association with this polymorphism under the over-dominant model of inheritance (OR=1.75, P=...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research