Effect of methanolic leaf extract of Telfairia occidentalis (Hook f.) on vaginal cytology, serum hormonal levels and ovarian histomorphology of female (Sprague —Dawley) albino rats

This study evaluated the effect of the oral administration of methanolic leaf extract ofT. occidentalis on vaginal cytology, serum hormone (progesterone and estrogen) levels, and histomorphology of the ovaries of female albino rat. Fifteen female albino rats were used for the study. They were randomly assigned to three groups of five rats each. The first group (A) served as the untreated control and received distilled water while the second group (B) and third (C) received 200 and 800  mg/kg body weight of the extract respectively for 21 days. Evaluation of vaginal cytology did not show any effect of the extract on the estrous cycle. The group C rats that received the highest dose (800 mg/kg body weight) had a significantly higher (p <  0.05) serum concentration of progesterone during the prestrus and estrus phases and a significant lower (p <  0.05) serum levels of oestrogen during the metestrus and diestrus. Histological examination of ovarian tissues of the different groups did not show obvious abnormalities.

Source: Comparative Clinical Pathology - October 19, 2016 Category: Pathology Source Type: research