Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Wen-Cai Liu, Fan Yang, Ran Zhang, Xuan Shi, Xin-Hua Lu, Yu-Shi Luan, Zhi-Long Xiu, Yue-Sheng Dong Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides’ structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. Graphical abstract

Source: Phytochemistry Letters - October 15, 2016 Category: Chemistry Source Type: research