A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.
Curr Opin Immunol. 2016 Oct 7;43:67-73
Authors: Roep BO, Kracht MJ, van Lummel M, Zaldumbide A
Abstract
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of the insulin-producing beta cells. Beta cell dysfunction caused by an inflammatory microenvironment is believed to trigger the peripheral activation of CD4 and CD8 autoreactive T cells. This review will compile post-transcriptional and post-translational modifications (PTM) involved in the generation of beta cell neoantigens and proposes a reconstruction of the sequence of events connecting environmental changes and autoimmunity.
PMID: 27723537 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - October 6, 2016 Category: Allergy & Immunology Authors: Roep BO, Kracht MJ, van Lummel M, Zaldumbide A Tags: Curr Opin Immunol Source Type: research