Associations between OPG and RANKL polymorphisms, vertebral fractures, and abdominal aortic calcification in community-dwelling older subjects: the Sao Paulo Ageing & amp; Health Study (SPAH)

ConclusionThis study showed that theOPG 209AA genotype was a risk factor for higher-grade VFs, theOPG 209A allele was protective for aortic calcification, and theOPG 1181C was a risk factor for aortic calcification, supporting the involvement ofOPG polymorphisms in the analyzed phenotypes and the concept that the related pathogenesis is multifactorial.

Source: Osteoporosis International - October 12, 2016 Category: Orthopaedics Source Type: research