Metabolites isolated from the rhizomes of Dorstenia contrajerva with anti-leishmanial activity

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Héctor A. Peniche-Pavía, Deisy Medrano-Nahuat, Luis W. Torres-Tapia, Mirza Mut-Martín, Rosario García-Miss, Sergio R. Peraza-Sánchez Two new 2-benzylbenzofurans, dorsjervin A (1) and dorsjervin B (2), were isolated together with other nine known compounds (3–11) from Dorstenia contrajerva. Structure elucidation of both compounds was done through UV, IR, 1D- and 2D-NMR experiments, and mass spectrometry. All of the isolated compounds were evaluated for an in vitro anti-leishmanial activity; compounds 7 and 8 were active, with IC50’s 4.9 and 2.9μM, respectively. This is the first report on prenylated flavonoids (1, 2, and 7) isolated from a species of Dorstenia in the Americas. Graphical abstract

Source: Phytochemistry Letters - October 10, 2016 Category: Chemistry Source Type: research