[Intravesical instillations in non-muscle-invasive bladder cancer (NMIBC). Prospects for thermochemotherapy].

[Intravesical instillations in non-muscle-invasive bladder cancer (NMIBC). Prospects for thermochemotherapy]. Prog Urol. 2016 Oct 3;: Authors: Irani J Abstract Non-muscle-invasive bladder cancer (NMIBC) is characterised by a high risk of recurrence when performing only a transurethral resection of the bladder (TURB). Intravesical instillations are performed postoperatively to decrease the rate of recurrence. The standard agents currently used are Mitomycin-C (MMC) or bacillus Calmette-Guérin (BCG). In order to further enhance the efficacy of the adjuvant treatments and/or diminish their side effects, alternative treatments are studied. Intravesical MMC combined with hyperthermia could be an interesting alternative active treatment for intermediate- and possibly high-risk NMIBC, and has been investigated in the past years. Two methods for achieving hyperthermia are described and presently evaluated: heating the bladder wall by the mean of an intravesical microwave generator (Synergo(®)) and heating the MMC before it is instilled in the bladder (Combat BRS(®)). LEVEL OF EVIDENCE: 5. PMID: 27712914 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research